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dc.contributor.authorChen, KYH
dc.contributor.authorBurgner, DP
dc.contributor.authorWong, TY
dc.contributor.authorSaw, SM
dc.contributor.authorQuek, SC
dc.contributor.authorPang, AYC
dc.contributor.authorLeo, SW
dc.contributor.authorWong, IB
dc.contributor.authorZannino, D
dc.contributor.authorCurtis, N
dc.contributor.authorCheung, M
dc.contributor.authorCheung, CY
dc.contributor.authorLim, TCW
dc.date.accessioned2020-12-22T03:54:12Z
dc.date.available2020-12-22T03:54:12Z
dc.date.issued2017-01-17
dc.identifierpii: srep40513
dc.identifier.citationChen, K. Y. H., Burgner, D. P., Wong, T. Y., Saw, S. M., Quek, S. C., Pang, A. Y. C., Leo, S. W., Wong, I. B., Zannino, D., Curtis, N., Cheung, M., Cheung, C. Y. & Lim, T. C. W. (2017). Evidence of Microvascular Changes in the Retina following Kawasaki Disease. SCIENTIFIC REPORTS, 7 (1), https://doi.org/10.1038/srep40513.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11343/257953
dc.description.abstractIt is unclear whether all children with Kawasaki disease (KD) have increased later cardiovascular risk. The retinal microvasculature reflects changes in the microcirculation and is associated with traditional cardiovascular risk factors and events. The aim of this study was to investigate retinal microvascular parameters in two populations of patients with previous KD and control participants. We performed case-control studies of 116 (57 patients and 59 control participants) Australian and 156 (78 patients and 78 control participants) Singaporean individuals, at least two years since their acute illness. Standardised retinal photographs were graded by trained technicians using a semi-automated software, which quantifies the retinal microvasculature (calibre, branching angle, fractal dimensions, and tortuosity). Retinal venules of Singaporean KD patients were 9.67 μm (95% CI 4.87 to 14.51, p < 0.001) larger than control participants following correction for traditional cardiovascular risk factors. An incremental increase in the size of retinal venules in those with coronary artery abnormalities was observed. There was limited evidence that retinal venules were larger in Australian KD patients with coronary artery abnormalities compared to control participants (7.34 μm, 95% CI 1.30 to 15.99, p = 0.10). Differences in retinal microvasculature were particularly evident in Singaporean KD patients. Larger retinal venules may reflect chronic inflammation and endothelial dysfunction, and are associated with coronary artery disease in adults.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.titleEvidence of Microvascular Changes in the Retina following Kawasaki Disease
dc.typeJournal Article
dc.identifier.doi10.1038/srep40513
melbourne.affiliation.departmentOphthalmology (Eye & Ear Hospital)
melbourne.affiliation.departmentPaediatrics (RCH)
melbourne.source.titleScientific Reports
melbourne.source.volume7
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1180475
melbourne.contributor.authorBurgner, David
melbourne.contributor.authorCurtis, Richard
melbourne.contributor.authorCheung, Michael
melbourne.contributor.authorChen, Katherine
melbourne.contributor.authorWong, Tien
dc.identifier.eissn2045-2322
melbourne.accessrightsOpen Access


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