University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Psychiatry
  • Psychiatry - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Psychiatry
  • Psychiatry - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Meta-analysis reveals associations between genetic variation in the 5 ' and 3 ' regions of Neuregulin-1 and schizophrenia

    Thumbnail
    Download
    Published version (469.1Kb)

    Citations
    Scopus
    Web of Science
    Altmetric
    24
    18
    Author
    Mostaid, MS; Mancuso, SG; Liu, C; Sundram, S; Pantelis, C; Everall, IP; Bousman, CA
    Date
    2017-01-17
    Source Title
    Translational Psychiatry
    Publisher
    SPRINGERNATURE
    University of Melbourne Author/s
    Pantelis, Christos; Mostaid, MD Shaki; Mancuso, Serafino; Everall, Ian; Bousman, Chad; Sundram, Suresh; Liu, Chenxing
    Affiliation
    Psychiatry
    Florey Department of Neuroscience and Mental Health
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Mostaid, M. S., Mancuso, S. G., Liu, C., Sundram, S., Pantelis, C., Everall, I. P. & Bousman, C. A. (2017). Meta-analysis reveals associations between genetic variation in the 5 ' and 3 ' regions of Neuregulin-1 and schizophrenia. TRANSLATIONAL PSYCHIATRY, 7 (1), https://doi.org/10.1038/tp.2016.279.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257954
    DOI
    10.1038/tp.2016.279
    Abstract
    Genetic, post-mortem and neuroimaging studies repeatedly implicate neuregulin-1 (NRG1) as a critical component in the pathophysiology of schizophrenia. Although a number of risk haplotypes along with several genetic polymorphisms in the 5' and 3' regions of NRG1 have been linked with schizophrenia, results have been mixed. To reconcile these conflicting findings, we conducted a meta-analysis examining 22 polymorphisms and two haplotypes in NRG1 among 16 720 cases, 20 449 controls and 2157 family trios. We found significant associations for three polymorphisms (rs62510682, rs35753505 and 478B14-848) at the 5'-end and two (rs2954041 and rs10503929) near the 3'-end of NRG1. Population stratification effects were found for the rs35753505 and 478B14-848(4) polymorphisms. There was evidence of heterogeneity for all significant markers and the findings were robust to publication bias. No significant haplotype associations were found. Our results suggest genetic variation at the 5' and 3' ends of NRG1 are associated with schizophrenia and provide renewed justification for further investigation of NRG1's role in the pathophysiology of schizophrenia.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [45689]
    • Florey Department of Neuroscience and Mental Health - Research Publications [1052]
    • Psychiatry - Research Publications [1103]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors