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dc.contributor.authorDeane, AM
dc.contributor.authorLittle, L
dc.contributor.authorBellomo, R
dc.contributor.authorChapman, MJ
dc.contributor.authorDavies, AR
dc.contributor.authorFerrie, S
dc.contributor.authorHorowitz, M
dc.contributor.authorHurford, S
dc.contributor.authorLange, K
dc.contributor.authorLitton, E
dc.contributor.authorMackle, D
dc.contributor.authorO'Connor, S
dc.contributor.authorParker, J
dc.contributor.authorPeake, SL
dc.contributor.authorPresneill, JJ
dc.contributor.authorRidley, EJ
dc.contributor.authorSingh, V
dc.contributor.authorvan Haren, F
dc.contributor.authorWilliams, P
dc.contributor.authorYoung, P
dc.contributor.authorIwashyna, TJ
dc.identifier.citationDeane, A. M., Little, L., Bellomo, R., Chapman, M. J., Davies, A. R., Ferrie, S., Horowitz, M., Hurford, S., Lange, K., Litton, E., Mackle, D., O'Connor, S., Parker, J., Peake, S. L., Presneill, J. J., Ridley, E. J., Singh, V., van Haren, F., Williams, P. ,... Iwashyna, T. J. (2020). Outcomes Six Months after Delivering 100% or 70% of Enteral Calorie Requirements during Critical Illness (TARGET) A Randomized Controlled Trial. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 201 (7), pp.814-822.
dc.description.abstractRationale: The long-term effects of delivering approximately 100% of recommended calorie intake via the enteral route during critical illness compared with a lesser amount of calories are unknown.Objectives: Our hypotheses were that achieving approximately 100% of recommended calorie intake during critical illness would increase quality-of-life scores, return to work, and key life activities and reduce death and disability 6 months later.Methods: We conducted a multicenter, blinded, parallel group, randomized clinical trial, with 3,957 mechanically ventilated critically ill adults allocated to energy-dense (1.5 kcal/ml) or routine (1.0 kcal/ml) enteral nutrition.Measurements and Main Results: Participants assigned energy-dense nutrition received more calories (percent recommended energy intake, mean [SD]; energy-dense: 103% [28] vs. usual: 69% [18]). Mortality at Day 180 was similar (560/1,895 [29.6%] vs. 539/1,920 [28.1%]; relative risk 1.05 [95% confidence interval, 0.95-1.16]). At a median (interquartile range) of 185 (182-193) days after randomization, 2,492 survivors were surveyed and reported similar quality of life (EuroQol five dimensions five-level quality-of-life questionnaire visual analog scale, median [interquartile range]: 75 [60-85]; group difference: 0 [95% confidence interval, 0-0]). Similar numbers of participants returned to work with no difference in hours worked or effectiveness at work (n = 818). There was no observed difference in disability (n = 1,208) or participation in key life activities (n = 705).Conclusions: The delivery of approximately 100% compared with 70% of recommended calorie intake during critical illness does not improve quality of life or functional outcomes or increase the number of survivors 6 months later.
dc.titleOutcomes Six Months after Delivering 100% or 70% of Enteral Calorie Requirements during Critical Illness (TARGET) A Randomized Controlled Trial
dc.typeJournal Article
melbourne.affiliation.departmentMedicine (RMH)
melbourne.affiliation.departmentCritical Care
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleAmerican Journal of Respiratory and Critical Care Medicine
melbourne.contributor.authorBellomo, Rinaldo
melbourne.contributor.authorDeane, Adam
melbourne.contributor.authorPresneill, Jeffrey
melbourne.accessrightsThis item is currently not available from this repository

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