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    The IMPORTance of the Nucleus during Flavivirus Replication

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    Author
    Lopez-Denman, AJ; Mackenzie, JM
    Date
    2017-01-01
    Source Title
    Viruses
    Publisher
    MDPI
    University of Melbourne Author/s
    Mackenzie, Jason; Lopez-Denman, Adam
    Affiliation
    Microbiology and Immunology
    Metadata
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    Document Type
    Journal Article
    Citations
    Lopez-Denman, A. J. & Mackenzie, J. M. (2017). The IMPORTance of the Nucleus during Flavivirus Replication. VIRUSES-BASEL, 9 (1), https://doi.org/10.3390/v9010014.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257972
    DOI
    10.3390/v9010014
    Abstract
    Flaviviruses are a large group of arboviruses of significant medical concern worldwide. With outbreaks a common occurrence, the need for efficient viral control is required more than ever. It is well understood that flaviviruses modulate the composition and structure of membranes in the cytoplasm that are crucial for efficient replication and evading immune detection. As the flavivirus genome consists of positive sense RNA, replication can occur wholly within the cytoplasm. What is becoming more evident is that some viral proteins also have the ability to translocate to the nucleus, with potential roles in replication and immune system perturbation. In this review, we discuss the current understanding of flavivirus nuclear localisation, and the function it has during flavivirus infection. We also describe-while closely related-the functional differences between similar viral proteins in their nuclear translocation.

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