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dc.contributor.authorLopez-Denman, AJ
dc.contributor.authorMackenzie, JM
dc.date.accessioned2020-12-22T03:59:06Z
dc.date.available2020-12-22T03:59:06Z
dc.date.issued2017-01-01
dc.identifierpii: v9010014
dc.identifier.citationLopez-Denman, A. J. & Mackenzie, J. M. (2017). The IMPORTance of the Nucleus during Flavivirus Replication. VIRUSES-BASEL, 9 (1), https://doi.org/10.3390/v9010014.
dc.identifier.issn1999-4915
dc.identifier.urihttp://hdl.handle.net/11343/257972
dc.description.abstractFlaviviruses are a large group of arboviruses of significant medical concern worldwide. With outbreaks a common occurrence, the need for efficient viral control is required more than ever. It is well understood that flaviviruses modulate the composition and structure of membranes in the cytoplasm that are crucial for efficient replication and evading immune detection. As the flavivirus genome consists of positive sense RNA, replication can occur wholly within the cytoplasm. What is becoming more evident is that some viral proteins also have the ability to translocate to the nucleus, with potential roles in replication and immune system perturbation. In this review, we discuss the current understanding of flavivirus nuclear localisation, and the function it has during flavivirus infection. We also describe-while closely related-the functional differences between similar viral proteins in their nuclear translocation.
dc.languageEnglish
dc.publisherMDPI
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleThe IMPORTance of the Nucleus during Flavivirus Replication
dc.typeJournal Article
dc.identifier.doi10.3390/v9010014
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.source.titleViruses
melbourne.source.volume9
melbourne.source.issue1
melbourne.identifier.nhmrc1004619
dc.rights.licenseCC BY
melbourne.elementsid1183074
melbourne.contributor.authorMackenzie, Jason
melbourne.contributor.authorLopez-Denman, Adam
dc.identifier.eissn1999-4915
melbourne.identifier.fundernameidNHMRC, 1004619
melbourne.accessrightsOpen Access


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