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    Genomic Insights into a Sustained National Outbreak of Yersinia pseudotuberculosis

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    Author
    Williamson, DA; Baines, SL; Carter, GP; da silva, AG; Ren, X; Sherwood, J; Dufour, M; Schultz, MB; French, NP; Seemann, T; ...
    Date
    2016-12-01
    Source Title
    Genome Biology and Evolution
    Publisher
    OXFORD UNIV PRESS
    University of Melbourne Author/s
    Baines, Sarah; Williamson, Deborah; Schultz, Mark; Seemann, Torsten; Stinear, Timothy; Howden, Benjamin; Carter, Glen; Goncalves Da Silva, Anders
    Affiliation
    Microbiology and Immunology
    Metadata
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    Document Type
    Journal Article
    Citations
    Williamson, D. A., Baines, S. L., Carter, G. P., da silva, A. G., Ren, X., Sherwood, J., Dufour, M., Schultz, M. B., French, N. P., Seemann, T., Stinear, T. P. & Howden, B. P. (2016). Genomic Insights into a Sustained National Outbreak of Yersinia pseudotuberculosis. GENOME BIOLOGY AND EVOLUTION, 8 (12), pp.3806-3814. https://doi.org/10.1093/gbe/evw285.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257977
    DOI
    10.1093/gbe/evw285
    Abstract
    In 2014, a sustained outbreak of yersiniosis due to Yersinia pseudotuberculosis occurred across all major cities in New Zealand (NZ), with a total of 220 laboratory-confirmed cases, representing one of the largest ever reported outbreaks of Y. pseudotuberculosis. Here, we performed whole genome sequencing of outbreak-associated isolates to produce the largest population analysis to date of Y. pseudotuberculosis, giving us unprecedented capacity to understand the emergence and evolution of the outbreak clone. Multivariate analysis incorporating our genomic and clinical epidemiological data strongly suggested a single point-source contamination of the food chain, with subsequent nationwide distribution of contaminated produce. We additionally uncovered significant diversity in key determinants of virulence, which we speculate may help explain the high morbidity linked to this outbreak.

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