Genomic Insights into a Sustained National Outbreak of Yersinia pseudotuberculosis
Web of Science
AuthorWilliamson, DA; Baines, SL; Carter, GP; da silva, AG; Ren, X; Sherwood, J; Dufour, M; Schultz, MB; French, NP; Seemann, T; ...
Source TitleGenome Biology and Evolution
PublisherOXFORD UNIV PRESS
University of Melbourne Author/sBaines, Sarah; Williamson, Deborah; Schultz, Mark; Seemann, Torsten; Stinear, Timothy; Howden, Benjamin; Carter, Glen; Goncalves Da Silva, Anders
AffiliationMicrobiology and Immunology
Document TypeJournal Article
CitationsWilliamson, D. A., Baines, S. L., Carter, G. P., da silva, A. G., Ren, X., Sherwood, J., Dufour, M., Schultz, M. B., French, N. P., Seemann, T., Stinear, T. P. & Howden, B. P. (2016). Genomic Insights into a Sustained National Outbreak of Yersinia pseudotuberculosis. GENOME BIOLOGY AND EVOLUTION, 8 (12), pp.3806-3814. https://doi.org/10.1093/gbe/evw285.
Access StatusOpen Access
In 2014, a sustained outbreak of yersiniosis due to Yersinia pseudotuberculosis occurred across all major cities in New Zealand (NZ), with a total of 220 laboratory-confirmed cases, representing one of the largest ever reported outbreaks of Y. pseudotuberculosis. Here, we performed whole genome sequencing of outbreak-associated isolates to produce the largest population analysis to date of Y. pseudotuberculosis, giving us unprecedented capacity to understand the emergence and evolution of the outbreak clone. Multivariate analysis incorporating our genomic and clinical epidemiological data strongly suggested a single point-source contamination of the food chain, with subsequent nationwide distribution of contaminated produce. We additionally uncovered significant diversity in key determinants of virulence, which we speculate may help explain the high morbidity linked to this outbreak.
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