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dc.contributor.authorWilliamson, DA
dc.contributor.authorBaines, SL
dc.contributor.authorCarter, GP
dc.contributor.authorda silva, AG
dc.contributor.authorRen, X
dc.contributor.authorSherwood, J
dc.contributor.authorDufour, M
dc.contributor.authorSchultz, MB
dc.contributor.authorFrench, NP
dc.contributor.authorSeemann, T
dc.contributor.authorStinear, TP
dc.contributor.authorHowden, BP
dc.date.accessioned2020-12-22T04:00:56Z
dc.date.available2020-12-22T04:00:56Z
dc.date.issued2016-12-01
dc.identifierpii: 2875729
dc.identifier.citationWilliamson, D. A., Baines, S. L., Carter, G. P., da silva, A. G., Ren, X., Sherwood, J., Dufour, M., Schultz, M. B., French, N. P., Seemann, T., Stinear, T. P. & Howden, B. P. (2016). Genomic Insights into a Sustained National Outbreak of Yersinia pseudotuberculosis. GENOME BIOLOGY AND EVOLUTION, 8 (12), pp.3806-3814. https://doi.org/10.1093/gbe/evw285.
dc.identifier.issn1759-6653
dc.identifier.urihttp://hdl.handle.net/11343/257977
dc.description.abstractIn 2014, a sustained outbreak of yersiniosis due to Yersinia pseudotuberculosis occurred across all major cities in New Zealand (NZ), with a total of 220 laboratory-confirmed cases, representing one of the largest ever reported outbreaks of Y. pseudotuberculosis. Here, we performed whole genome sequencing of outbreak-associated isolates to produce the largest population analysis to date of Y. pseudotuberculosis, giving us unprecedented capacity to understand the emergence and evolution of the outbreak clone. Multivariate analysis incorporating our genomic and clinical epidemiological data strongly suggested a single point-source contamination of the food chain, with subsequent nationwide distribution of contaminated produce. We additionally uncovered significant diversity in key determinants of virulence, which we speculate may help explain the high morbidity linked to this outbreak.
dc.languageEnglish
dc.publisherOXFORD UNIV PRESS
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0
dc.titleGenomic Insights into a Sustained National Outbreak of Yersinia pseudotuberculosis
dc.typeJournal Article
dc.identifier.doi10.1093/gbe/evw285
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.source.titleGenome Biology and Evolution
melbourne.source.volume8
melbourne.source.issue12
melbourne.source.pages3806-3814
melbourne.identifier.nhmrc1105905
dc.rights.licenseCC BY-NC
melbourne.elementsid1183176
melbourne.contributor.authorBaines, Sarah
melbourne.contributor.authorWilliamson, Deborah
melbourne.contributor.authorSchultz, Mark
melbourne.contributor.authorSeemann, Torsten
melbourne.contributor.authorStinear, Timothy
melbourne.contributor.authorHowden, Benjamin
melbourne.contributor.authorCarter, Glen
melbourne.contributor.authorGoncalves Da Silva, Anders
dc.identifier.eissn1759-6653
melbourne.identifier.fundernameidNHMRC, 1105905
melbourne.accessrightsOpen Access


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