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    A systematic review of adrenarche as a sensitive period in neurobiological development and mental health

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    Author
    Byrne, ML; Whittle, S; Vijayakumar, N; Dennison, M; Simmons, JG; Allen, NB
    Date
    2017-06-01
    Source Title
    Developmental Cognitive Neuroscience
    Publisher
    ELSEVIER SCI LTD
    University of Melbourne Author/s
    Simmons, Julian; Whittle, Sarah; Allen, Nicholas; Dennison, Megan
    Affiliation
    Psychiatry
    Melbourne School of Psychological Sciences
    Metadata
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    Document Type
    Journal Article
    Citations
    Byrne, M. L., Whittle, S., Vijayakumar, N., Dennison, M., Simmons, J. G. & Allen, N. B. (2017). A systematic review of adrenarche as a sensitive period in neurobiological development and mental health. DEVELOPMENTAL COGNITIVE NEUROSCIENCE, 25, pp.12-28. https://doi.org/10.1016/j.dcn.2016.12.004.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/258001
    DOI
    10.1016/j.dcn.2016.12.004
    Abstract
    Substantial hormonal and neurobiological changes occur during puberty, and are widely argued to render this period of life a sensitive period in terms of risk for mental health problems. However, there is a paucity of research focusing on adrenarche, the earlier phase of pubertal development. Furthermore, there is a limited understanding of the association between adrenarche and neural development during this phase of life. We systematically reviewed research examining human adrenarcheal development as operationalized by hormonal levels of DHEA and DHEA-S, in relation to indices of mental health (Systematic Review 1). We then reviewed the limited amount of literature that has examined the association between adrenarcheal development and brain structure or function (Systematic Review 2). In general, studies showed that earlier timing of adrenarche was associated with greater mental health symptoms, and there is emerging support that brain development plays a role in this relationship. However, several methodological inconsistencies were noted. We propose that future research in this area test a theoretical model of adrenarche as a sensitive period of neurobiological development, whereby timing of exposure to hormones interacts with brain development, biological sex, and psychosocial stress to influence environmental sensitivity and risk for mental health problems through adolescence.

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