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dc.contributor.authorHor, JL
dc.contributor.authorHeath, WR
dc.contributor.authorMueller, SN
dc.date.accessioned2020-12-22T04:10:45Z
dc.date.available2020-12-22T04:10:45Z
dc.date.issued2017-01-23
dc.identifierpii: srep41091
dc.identifier.citationHor, J. L., Heath, W. R. & Mueller, S. N. (2017). Neutrophils are dispensable in the modulation of T cell immunity against cutaneous HSV-1 infection. SCIENTIFIC REPORTS, 7 (1), https://doi.org/10.1038/srep41091.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11343/258012
dc.description.abstractNeutrophils rapidly infiltrate sites of inflammation during peripheral infection or tissue injury. In addition to their well described roles as pro-inflammatory phagocytes responsible for pathogen clearance, recent studies have demonstrated a broader functional repertoire including mediating crosstalk between innate and adaptive arms of the immune system. Specifically, neutrophils have been proposed to mediate antigen transport to lymph nodes (LN) to modulate T cell priming and to influence T cell migration to infected tissues. Using a mouse model of cutaneous herpes simplex virus type 1 (HSV-1) infection we explored potential contributions of neutrophils toward anti-viral immunity. While a transient, early influx of neutrophils was triggered by dermal scarification, we did not detect migration of neutrophils from the skin to LN. Furthermore, despite recruitment of neutrophils into LN from the blood, priming and expansion of CD4+ and CD8+ T cells was unaffected following neutrophil depletion. Finally, we found that neutrophils were dispensable for the migration of effector T cells into infected skin. Our study suggests that the immunomodulatory roles of neutrophils toward adaptive immunity may be context-dependent, and are likely determined by the type of pathogen and anatomical site of infection.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleNeutrophils are dispensable in the modulation of T cell immunity against cutaneous HSV-1 infection
dc.typeJournal Article
dc.identifier.doi10.1038/srep41091
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.source.titleScientific Reports
melbourne.source.volume7
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1183955
melbourne.contributor.authorHeath, William
melbourne.contributor.authorMueller, Scott
melbourne.contributor.authorHOR, JYH LIANG
dc.identifier.eissn2045-2322
melbourne.accessrightsOpen Access


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