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    Spleen Volume Variation in Patients with Locally Advanced Non-Small Cell Lung Cancer Receiving Platinum-Based Chemo-Radiotherapy

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    12
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    Author
    Wen, SW; Everitt, SJ; Bedo, J; Chabrot, M; Ball, DL; Solomon, B; MacManus, M; Hicks, RJ; Moeller, A; Leimgruber, A
    Date
    2015-11-24
    Source Title
    PLoS One
    Publisher
    PUBLIC LIBRARY SCIENCE
    University of Melbourne Author/s
    Hicks, Rodney; Everitt, Sarah; Bedo, Justin; Ball, David; MacManus, Michael; Solomon, Benjamin
    Affiliation
    Medicine and Radiology
    Sir Peter MacCallum Department of Oncology
    Computing and Information Systems
    Metadata
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    Document Type
    Journal Article
    Citations
    Wen, S. W., Everitt, S. J., Bedo, J., Chabrot, M., Ball, D. L., Solomon, B., MacManus, M., Hicks, R. J., Moeller, A. & Leimgruber, A. (2015). Spleen Volume Variation in Patients with Locally Advanced Non-Small Cell Lung Cancer Receiving Platinum-Based Chemo-Radiotherapy. PLOS ONE, 10 (11), https://doi.org/10.1371/journal.pone.0142608.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/258058
    DOI
    10.1371/journal.pone.0142608
    Abstract
    There is renewed interest in the immune regulatory role of the spleen in oncology. To date, very few studies have examined macroscopic variations of splenic volume in the setting of cancer, prior to or during therapy, especially in humans. Changes in splenic volume may be associated with changes in splenic function. The purpose of this study was to investigate variations in spleen volume in NSCLC patients during chemo-radiotherapy. Sixty patients with stage I-IIIB NSCLC underwent radiotherapy (60 Gy/30 fractions) for six weeks with concomitant carboplatin/paclitaxel (Ca/P; n = 32) or cisplatin/etoposide (Ci/E; n = 28). A baseline PET/CT scan was performed within 2 weeks prior to treatment and during Weeks 2 and 4 of chemo-radiotherapy. Spleen volume was measured by contouring all CT slices. Significant macroscopic changes in splenic volume occurred early after the commencement of treatment. A significant decrease in spleen volume was observed for 66% of Ca/P and 79% of Ci/E patients between baseline and Week 2. Spleen volume was decreased by 14.2% for Ca/P (p<0.001) and 19.3% for Ci/E (p<0.001) patients. By Week 4, spleen volume was still significantly decreased for Ca/P patients compared to baseline, while for Ci/E patients, spleen volume returned to above baseline levels. This is the first report demonstrating macroscopic changes in the spleen in NSCLC patients undergoing radical chemo-radiotherapy that can be visualized by non-invasive imaging.

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