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dc.contributor.authorWen, SW
dc.contributor.authorEveritt, SJ
dc.contributor.authorBedo, J
dc.contributor.authorChabrot, M
dc.contributor.authorBall, DL
dc.contributor.authorSolomon, B
dc.contributor.authorMacManus, M
dc.contributor.authorHicks, RJ
dc.contributor.authorMoeller, A
dc.contributor.authorLeimgruber, A
dc.date.accessioned2020-12-22T04:23:40Z
dc.date.available2020-12-22T04:23:40Z
dc.date.issued2015-11-24
dc.identifierpii: PONE-D-15-29811
dc.identifier.citationWen, S. W., Everitt, S. J., Bedo, J., Chabrot, M., Ball, D. L., Solomon, B., MacManus, M., Hicks, R. J., Moeller, A. & Leimgruber, A. (2015). Spleen Volume Variation in Patients with Locally Advanced Non-Small Cell Lung Cancer Receiving Platinum-Based Chemo-Radiotherapy. PLOS ONE, 10 (11), https://doi.org/10.1371/journal.pone.0142608.
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11343/258058
dc.description.abstractThere is renewed interest in the immune regulatory role of the spleen in oncology. To date, very few studies have examined macroscopic variations of splenic volume in the setting of cancer, prior to or during therapy, especially in humans. Changes in splenic volume may be associated with changes in splenic function. The purpose of this study was to investigate variations in spleen volume in NSCLC patients during chemo-radiotherapy. Sixty patients with stage I-IIIB NSCLC underwent radiotherapy (60 Gy/30 fractions) for six weeks with concomitant carboplatin/paclitaxel (Ca/P; n = 32) or cisplatin/etoposide (Ci/E; n = 28). A baseline PET/CT scan was performed within 2 weeks prior to treatment and during Weeks 2 and 4 of chemo-radiotherapy. Spleen volume was measured by contouring all CT slices. Significant macroscopic changes in splenic volume occurred early after the commencement of treatment. A significant decrease in spleen volume was observed for 66% of Ca/P and 79% of Ci/E patients between baseline and Week 2. Spleen volume was decreased by 14.2% for Ca/P (p<0.001) and 19.3% for Ci/E (p<0.001) patients. By Week 4, spleen volume was still significantly decreased for Ca/P patients compared to baseline, while for Ci/E patients, spleen volume returned to above baseline levels. This is the first report demonstrating macroscopic changes in the spleen in NSCLC patients undergoing radical chemo-radiotherapy that can be visualized by non-invasive imaging.
dc.languageEnglish
dc.publisherPUBLIC LIBRARY SCIENCE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleSpleen Volume Variation in Patients with Locally Advanced Non-Small Cell Lung Cancer Receiving Platinum-Based Chemo-Radiotherapy
dc.typeJournal Article
dc.identifier.doi10.1371/journal.pone.0142608
melbourne.affiliation.departmentComputing and Information Systems
melbourne.affiliation.departmentSir Peter MacCallum Department of Oncology
melbourne.affiliation.departmentMedicine (St Vincent's)
melbourne.affiliation.facultyEngineering and Information Technology
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titlePLoS One
melbourne.source.volume10
melbourne.source.issue11
melbourne.identifier.nhmrc1003895
dc.rights.licenseCC BY
melbourne.elementsid1025393
melbourne.contributor.authorHicks, Rodney
melbourne.contributor.authorEveritt, Sarah
melbourne.contributor.authorBedo, Justin
melbourne.contributor.authorBall, David
melbourne.contributor.authorMacManus, Michael
melbourne.contributor.authorSolomon, Benjamin
dc.identifier.eissn1932-6203
melbourne.identifier.fundernameidNHMRC, 1003895
melbourne.accessrightsOpen Access


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