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dc.contributor.authorOuattara, A
dc.contributor.authorBarry, AE
dc.contributor.authorDutta, S
dc.contributor.authorRemarque, EJ
dc.contributor.authorBeeson, JG
dc.contributor.authorPlowe, CV
dc.date.accessioned2020-12-22T04:24:16Z
dc.date.available2020-12-22T04:24:16Z
dc.date.issued2015-12-22
dc.identifierpii: S0264-410X(15)01414-0
dc.identifier.citationOuattara, A., Barry, A. E., Dutta, S., Remarque, E. J., Beeson, J. G. & Plowe, C. V. (2015). Designing malaria vaccines to circumvent antigen variability. VACCINE, 33 (52), pp.7506-7512. https://doi.org/10.1016/j.vaccine.2015.09.110.
dc.identifier.issn0264-410X
dc.identifier.urihttp://hdl.handle.net/11343/258060
dc.description.abstractProspects for malaria eradication will be greatly enhanced by an effective vaccine, but parasite genetic diversity poses a major impediment to malaria vaccine efficacy. In recent pre-clinical and field trials, vaccines based on polymorphic Plasmodium falciparum antigens have shown efficacy only against homologous strains, raising the specter of allele-specific immunity such as that which plagues vaccines against influenza and HIV. The most advanced malaria vaccine, RTS,S, targets relatively conserved epitopes on the P. falciparum circumsporozoite protein. After more than 40 years of development and testing, RTS,S, has shown significant but modest efficacy against clinical malaria in phase 2 and 3 trials. Ongoing phase 2 studies of an irradiated sporozoite vaccine will ascertain whether the full protection against homologous experimental malaria challenge conferred by high doses of a whole organism vaccine can provide protection against diverse strains in the field. Here we review and evaluate approaches being taken to design broadly cross-protective malaria vaccines.
dc.languageEnglish
dc.publisherELSEVIER SCI LTD
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleDesigning malaria vaccines to circumvent antigen variability
dc.typeJournal Article
dc.identifier.doi10.1016/j.vaccine.2015.09.110
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.source.titleVaccine
melbourne.source.volume33
melbourne.source.issue52
melbourne.source.pages7506-7512
dc.rights.licenseCC BY
melbourne.elementsid1025737
melbourne.contributor.authorBarry, Alyssa
dc.identifier.eissn1873-2518
melbourne.accessrightsOpen Access


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