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    Transcriptional profiling of the epigenetic regulator Smchd1

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    Author
    Liu, R; Chen, K; Jansz, N; Blewitt, ME; Ritchie, ME
    Date
    2016-03-01
    Source Title
    Genomics Data
    Publisher
    ELSEVIER SCIENCE BV
    University of Melbourne Author/s
    Blewitt, Marnie; Ritchie, Matthew; Jansz, Natasha; Chen, Kelan
    Affiliation
    Medical Biology (W.E.H.I.)
    Metadata
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    Document Type
    Journal Article
    Citations
    Liu, R., Chen, K., Jansz, N., Blewitt, M. E. & Ritchie, M. E. (2016). Transcriptional profiling of the epigenetic regulator Smchd1. GENOMICS DATA, 7, pp.144-147. https://doi.org/10.1016/j.gdata.2015.12.027.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/258064
    DOI
    10.1016/j.gdata.2015.12.027
    Abstract
    Smchd1 is an epigenetic repressor with important functions in healthy cellular processes and disease. To elucidate its role in transcriptional regulation, we performed two independent genome-wide RNA-sequencing studies comparing wild-type and Smchd1 null samples in neural stem cells and lymphoma cell lines. Using an R-based analysis pipeline that accommodates observational and sample-specific weights in the linear modeling, we identify key genes dysregulated by Smchd1 deletion such as clustered protocadherins in the neural stem cells and imprinted genes in both experiments. Here we provide a detailed description of this analysis, from quality control to read mapping and differential expression analysis. These data sets are publicly available from the Gene Expression Omnibus database (accession numbers GSE64099 and GSE65747).

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