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dc.contributor.authorLiu, R
dc.contributor.authorChen, K
dc.contributor.authorJansz, N
dc.contributor.authorBlewitt, ME
dc.contributor.authorRitchie, ME
dc.date.accessioned2020-12-22T04:25:13Z
dc.date.available2020-12-22T04:25:13Z
dc.date.issued2016-03-01
dc.identifierpii: S2213-5960(15)30130-6
dc.identifier.citationLiu, R., Chen, K., Jansz, N., Blewitt, M. E. & Ritchie, M. E. (2016). Transcriptional profiling of the epigenetic regulator Smchd1. GENOMICS DATA, 7, pp.144-147. https://doi.org/10.1016/j.gdata.2015.12.027.
dc.identifier.issn2213-5960
dc.identifier.urihttp://hdl.handle.net/11343/258064
dc.description.abstractSmchd1 is an epigenetic repressor with important functions in healthy cellular processes and disease. To elucidate its role in transcriptional regulation, we performed two independent genome-wide RNA-sequencing studies comparing wild-type and Smchd1 null samples in neural stem cells and lymphoma cell lines. Using an R-based analysis pipeline that accommodates observational and sample-specific weights in the linear modeling, we identify key genes dysregulated by Smchd1 deletion such as clustered protocadherins in the neural stem cells and imprinted genes in both experiments. Here we provide a detailed description of this analysis, from quality control to read mapping and differential expression analysis. These data sets are publicly available from the Gene Expression Omnibus database (accession numbers GSE64099 and GSE65747).
dc.languageEnglish
dc.publisherELSEVIER SCIENCE BV
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleTranscriptional profiling of the epigenetic regulator Smchd1
dc.typeJournal Article
dc.identifier.doi10.1016/j.gdata.2015.12.027
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.source.titleGenomics Data
melbourne.source.volume7
melbourne.source.pages144-147
dc.rights.licenseCC BY
melbourne.elementsid1026615
melbourne.contributor.authorBlewitt, Marnie
melbourne.contributor.authorRitchie, Matthew
melbourne.contributor.authorJansz, Natasha
melbourne.contributor.authorChen, Kelan
dc.identifier.eissn2213-5960
melbourne.accessrightsOpen Access


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