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dc.contributor.authorGnanadhas, DP
dc.contributor.authorElango, M
dc.contributor.authorJanardhanraj, S
dc.contributor.authorSrinandan, CS
dc.contributor.authorDatey, A
dc.contributor.authorStrugnell, RA
dc.contributor.authorGopalan, J
dc.contributor.authorChakravortty, D
dc.date.accessioned2020-12-22T04:26:00Z
dc.date.available2020-12-22T04:26:00Z
dc.date.issued2015-12-10
dc.identifierpii: srep17440
dc.identifier.citationGnanadhas, D. P., Elango, M., Janardhanraj, S., Srinandan, C. S., Datey, A., Strugnell, R. A., Gopalan, J. & Chakravortty, D. (2015). Successful treatment of biofilm infections using shock waves combined with antibiotic therapy. SCIENTIFIC REPORTS, 5 (1), https://doi.org/10.1038/srep17440.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11343/258067
dc.description.abstractMany bacteria secrete a highly hydrated framework of extracellular polymer matrix on suitable substrates and embed within the matrix to form a biofilm. Bacterial biofilms are observed on many medical devices, endocarditis, periodontitis and lung infections in cystic fibrosis patients. Bacteria in biofilm are protected from antibiotics and >1,000 times of the minimum inhibitory concentration may be required to treat biofilm infections. Here, we demonstrated that shock waves could be used to remove Salmonella, Pseudomonas and Staphylococcus biofilms in urinary catheters. The studies were extended to a Pseudomonas chronic pneumonia lung infection and Staphylococcus skin suture infection model in mice. The biofilm infections in mice, treated with shock waves became susceptible to antibiotics, unlike untreated biofilms. Mice exposed to shock waves responded to ciprofloxacin treatment, while ciprofloxacin alone was ineffective in treating the infection. These results demonstrate for the first time that, shock waves, combined with antibiotic treatment can be used to treat biofilm infection on medical devices as well as in situ infections.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.titleSuccessful treatment of biofilm infections using shock waves combined with antibiotic therapy
dc.typeJournal Article
dc.identifier.doi10.1038/srep17440
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.source.titleScientific Reports
melbourne.source.volume5
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1026795
melbourne.contributor.authorStrugnell, Richard
dc.identifier.eissn2045-2322
melbourne.accessrightsOpen Access


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