dc.contributor.author | Sagulenko, V | |
dc.contributor.author | Lawlor, KE | |
dc.contributor.author | Vince, JE | |
dc.date.accessioned | 2020-12-22T04:26:31Z | |
dc.date.available | 2020-12-22T04:26:31Z | |
dc.date.issued | 2016-01-13 | |
dc.identifier | pii: 10.1186/s13075-015-0910-0 | |
dc.identifier.citation | Sagulenko, V., Lawlor, K. E. & Vince, J. E. (2016). New insights into the regulation of innate immunity by caspase-8. ARTHRITIS RESEARCH & THERAPY, 18 (1), https://doi.org/10.1186/s13075-015-0910-0. | |
dc.identifier.issn | 1478-6354 | |
dc.identifier.uri | http://hdl.handle.net/11343/258069 | |
dc.description.abstract | Caspase-8 is required for extrinsic apoptosis, but is also central for preventing a pro-inflammatory receptor interacting protein kinase (RIPK) 3-mixed lineage kinase domain-like (MLKL)-dependent cell death pathway termed necroptosis. Despite these critical cellular functions, the impact of capase-8 deletion in the myeloid cell lineage, which forms the basis for innate immune responses, has remained unclear. In a recent article in Arthritis Research & Therapy, Cuda et al. report that myeloid cell-restricted caspase-8 loss leads to a very mild RIPK3-dependent inflammatory phenotype. The presented results suggest that inflammation does not arise exclusively because of RIPK3-mediated necroptotic death but that, in the absence of caspase-8, RIPK1 and RIPK3 enhance microbiome-driven Toll-like receptor-induced pro-inflammatory cytokine production. | |
dc.language | English | |
dc.publisher | BIOMED CENTRAL LTD | |
dc.title | New insights into the regulation of innate immunity by caspase-8 | |
dc.type | Journal Article | |
dc.identifier.doi | 10.1186/s13075-015-0910-0 | |
melbourne.affiliation.department | Medical Biology (W.E.H.I.) | |
melbourne.source.title | Arthritis Research and Therapy | |
melbourne.source.volume | 18 | |
melbourne.source.issue | 1 | |
dc.rights.license | CC BY | |
melbourne.elementsid | 1026933 | |
melbourne.contributor.author | Vince, James | |
melbourne.contributor.author | Lawlor, Kathryn | |
dc.identifier.eissn | 1478-6362 | |
melbourne.accessrights | Open Access | |