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    Malaria Epidemiology and Control within the International Centers of Excellence for Malaria Research

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    Author
    Moss, WJ; Dorsey, G; Mueller, I; Laufer, MK; Krogstad, DJ; Vinetz, JM; Guzman, M; Rosas-Aguirre, AM; Herrera, S; Arevalo-Herrera, M; ...
    Date
    2015-09-01
    Source Title
    American Journal of Tropical Medicine and Hygiene
    Publisher
    AMER SOC TROP MED & HYGIENE
    University of Melbourne Author/s
    Mueller, Ivo
    Affiliation
    Medical Biology (W.E.H.I.)
    Metadata
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    Document Type
    Journal Article
    Citations
    Moss, W. J., Dorsey, G., Mueller, I., Laufer, M. K., Krogstad, D. J., Vinetz, J. M., Guzman, M., Rosas-Aguirre, A. M., Herrera, S., Arevalo-Herrera, M., Chery, L., Kumar, A., Mohapatra, P. K., Ramanathapuram, L., Srivastava, H. C., Cui, L., Zhou, G., Parker, D. M., Nankabirwa, J. & Kazura, J. W. (2015). Malaria Epidemiology and Control within the International Centers of Excellence for Malaria Research. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 93 (3), pp.5-15. https://doi.org/10.4269/ajtmh.15-0006.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/258071
    DOI
    10.4269/ajtmh.15-0006
    Abstract
    Understanding the epidemiological features and metrics of malaria in endemic populations is a key component to monitoring and quantifying the impact of current and past control efforts to inform future ones. The International Centers of Excellence for Malaria Research (ICEMR) has the opportunity to evaluate the impact of malaria control interventions across endemic regions that differ in the dominant Plasmodium species, mosquito vector species, resistance to antimalarial drugs and human genetic variants thought to confer protection from infection and clinical manifestations of plasmodia infection. ICEMR programs are conducting field studies at multiple sites with the aim of generating standardized surveillance data to improve the understanding of malaria transmission and to monitor and evaluate the impact of interventions to inform malaria control and elimination programs. In addition, these epidemiological studies provide a vast source of biological samples linked to clinical and environmental "meta-data" to support translational studies of interactions between the parasite, human host, and mosquito vector. Importantly, epidemiological studies at the ICEMR field sites are integrated with entomological studies, including the measurement of the entomological inoculation rate, human biting index, and insecticide resistance, as well as studies of parasite genetic diversity and antimalarial drug resistance.

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