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    Acute Anterior Uveitis in a Patient Taking Fingolimod (FTY720) for Multiple Sclerosis

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    Author
    Mack, HG; Tien, MC-H; White, OB
    Date
    2016-09-01
    Source Title
    Case Reports in Ophthalmology
    Publisher
    KARGER
    University of Melbourne Author/s
    White, Owen; Mack, Heather
    Affiliation
    Medicine and Radiology
    Ophthalmology (Eye & Ear Hospital)
    Metadata
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    Document Type
    Journal Article
    Citations
    Mack, H. G., Tien, M. C. -H. & White, O. B. (2016). Acute Anterior Uveitis in a Patient Taking Fingolimod (FTY720) for Multiple Sclerosis. CASE REPORTS IN OPHTHALMOLOGY, 7 (3), pp.284-288. https://doi.org/10.1159/000453392.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/258092
    DOI
    10.1159/000453392
    Abstract
    Fingolimod is an oral sphingosine-1-phosphate (S1P) receptor modulator and the first oral therapy for relapsing-remitting multiple sclerosis. Its use has been complicated by a low rate of cystoid macular edema usually in the first 3 months after commencement of the medication. We report the case of a 34-year-old male with relapsing-remitting multiple sclerosis, who developed acute anterior uveitis on day 5 of fingolimod treatment. He responded to appropriate treatment and cessation of drug, but developed low-grade chronic anterior uveitis without cystoid macular edema. We discuss possible mechanisms of uveitis onset in this group of patients. Urgent ophthalmological review is recommended for patients receiving fingolimod therapy who develop a red, painful eye, which may occur within 5 days of fingolimod treatment initiation.

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