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  • Sir Peter MacCallum Department of Oncology
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    Therapeutic Approaches Targeting MYC-Driven Prostate Cancer

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    Author
    Rebello, RJ; Pearson, RB; Hannan, RD; Furic, L
    Date
    2017-02-01
    Source Title
    Genes
    Publisher
    MDPI
    University of Melbourne Author/s
    Hannan, Ross; Pearson, Richard; Furic, Luc
    Affiliation
    Sir Peter MacCallum Department of Oncology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Rebello, R. J., Pearson, R. B., Hannan, R. D. & Furic, L. (2017). Therapeutic Approaches Targeting MYC-Driven Prostate Cancer. GENES, 8 (2), https://doi.org/10.3390/genes8020071.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/258105
    DOI
    10.3390/genes8020071
    Abstract
    The transcript encoding the proto-oncogene MYC is commonly overexpressed in prostate cancer (PC). MYC protein abundance is also increased in the majority of cases of advanced and metastatic castrate-resistant PC (mCRPC). Accordingly, the MYC-directed transcriptional program directly contributes to PC by upregulating the expression of a number of pro-tumorigenic factors involved in cell growth and proliferation. A key cellular process downstream of MYC activity is the regulation of ribosome biogenesis which sustains tumor growth. MYC activity also cooperates with the dysregulation of the phosphoinositol-3-kinase (PI3K)/AKT/mTOR pathway to promote PC cell survival. Recent advances in the understanding of these interactions through the use of animal models have provided significant insight into the therapeutic efficacy of targeting MYC activity by interfering with its transcriptional program, and indirectly by targeting downstream cellular events linked to MYC transformation potential.

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