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dc.contributor.authorRebello, RJ
dc.contributor.authorPearson, RB
dc.contributor.authorHannan, RD
dc.contributor.authorFuric, L
dc.date.accessioned2020-12-22T04:37:43Z
dc.date.available2020-12-22T04:37:43Z
dc.date.issued2017-02-01
dc.identifierpii: genes8020071
dc.identifier.citationRebello, R. J., Pearson, R. B., Hannan, R. D. & Furic, L. (2017). Therapeutic Approaches Targeting MYC-Driven Prostate Cancer. GENES, 8 (2), https://doi.org/10.3390/genes8020071.
dc.identifier.issn2073-4425
dc.identifier.urihttp://hdl.handle.net/11343/258105
dc.description.abstractThe transcript encoding the proto-oncogene MYC is commonly overexpressed in prostate cancer (PC). MYC protein abundance is also increased in the majority of cases of advanced and metastatic castrate-resistant PC (mCRPC). Accordingly, the MYC-directed transcriptional program directly contributes to PC by upregulating the expression of a number of pro-tumorigenic factors involved in cell growth and proliferation. A key cellular process downstream of MYC activity is the regulation of ribosome biogenesis which sustains tumor growth. MYC activity also cooperates with the dysregulation of the phosphoinositol-3-kinase (PI3K)/AKT/mTOR pathway to promote PC cell survival. Recent advances in the understanding of these interactions through the use of animal models have provided significant insight into the therapeutic efficacy of targeting MYC activity by interfering with its transcriptional program, and indirectly by targeting downstream cellular events linked to MYC transformation potential.
dc.languageEnglish
dc.publisherMDPI
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleTherapeutic Approaches Targeting MYC-Driven Prostate Cancer
dc.typeJournal Article
dc.identifier.doi10.3390/genes8020071
melbourne.affiliation.departmentSir Peter MacCallum Department of Oncology
melbourne.source.titleGenes
melbourne.source.volume8
melbourne.source.issue2
melbourne.identifier.nhmrc1053792
melbourne.identifier.nhmrc1004881
dc.rights.licenseCC BY
melbourne.elementsid1184972
melbourne.contributor.authorHannan, Ross
melbourne.contributor.authorPearson, Richard
melbourne.contributor.authorFuric, Luc
melbourne.contributor.authorRebello, Richard
dc.identifier.eissn2073-4425
melbourne.identifier.fundernameidNHMRC, 1053792
melbourne.identifier.fundernameidNHMRC, 1004881
melbourne.accessrightsOpen Access


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