Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement

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    Author
    Smith, N; Pietrancosta, N; Davidson, S; Dutrieux, J; Chauveau, L; Cutolo, P; Dy, M; Scott-Algara, D; Manoury, B; Zirafi, O; ...
    Date
    2017-02-09
    Source Title
    Nature Communications
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    Davidson, Sophia
    Affiliation
    Medical Biology (W.E.H.I.)
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    Document Type
    Journal Article
    Citations
    Smith, N., Pietrancosta, N., Davidson, S., Dutrieux, J., Chauveau, L., Cutolo, P., Dy, M., Scott-Algara, D., Manoury, B., Zirafi, O., McCort-Tranchepain, I., Durroux, T., Bachelerie, F., Schwartz, O., Muench, J., Wack, A., Nisole, S. & Herbeuval, J. -P. (2017). Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement. NATURE COMMUNICATIONS, 8 (1), https://doi.org/10.1038/ncomms14253.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/258137
    DOI
    10.1038/ncomms14253
    Abstract
    Plasmacytoid dendritic cells (pDC) are specialized in secretion of type I interferon in response to pathogens. Here we show that natural monoamines and synthetic amines inhibit pDC activation by RNA viruses. Furthermore, a synthetic analogue of histamine reduces type I interferon production in a mouse model of influenza infection. We identify CXC chemokine receptor 4 (CXCR4) as a receptor used by amines to inhibit pDC. Our study establishes a functional link between natural amines and the innate immune system and identifies CXCR4 as a potential 'on-off' switch of pDC activity with therapeutic potential.

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