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dc.contributor.authorSmith, N
dc.contributor.authorPietrancosta, N
dc.contributor.authorDavidson, S
dc.contributor.authorDutrieux, J
dc.contributor.authorChauveau, L
dc.contributor.authorCutolo, P
dc.contributor.authorDy, M
dc.contributor.authorScott-Algara, D
dc.contributor.authorManoury, B
dc.contributor.authorZirafi, O
dc.contributor.authorMcCort-Tranchepain, I
dc.contributor.authorDurroux, T
dc.contributor.authorBachelerie, F
dc.contributor.authorSchwartz, O
dc.contributor.authorMuench, J
dc.contributor.authorWack, A
dc.contributor.authorNisole, S
dc.contributor.authorHerbeuval, J-P
dc.date.accessioned2020-12-22T04:46:13Z
dc.date.available2020-12-22T04:46:13Z
dc.date.issued2017-02-09
dc.identifierpii: ncomms14253
dc.identifier.citationSmith, N., Pietrancosta, N., Davidson, S., Dutrieux, J., Chauveau, L., Cutolo, P., Dy, M., Scott-Algara, D., Manoury, B., Zirafi, O., McCort-Tranchepain, I., Durroux, T., Bachelerie, F., Schwartz, O., Muench, J., Wack, A., Nisole, S. & Herbeuval, J. -P. (2017). Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement. NATURE COMMUNICATIONS, 8 (1), https://doi.org/10.1038/ncomms14253.
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/11343/258137
dc.description.abstractPlasmacytoid dendritic cells (pDC) are specialized in secretion of type I interferon in response to pathogens. Here we show that natural monoamines and synthetic amines inhibit pDC activation by RNA viruses. Furthermore, a synthetic analogue of histamine reduces type I interferon production in a mouse model of influenza infection. We identify CXC chemokine receptor 4 (CXCR4) as a receptor used by amines to inhibit pDC. Our study establishes a functional link between natural amines and the innate immune system and identifies CXCR4 as a potential 'on-off' switch of pDC activity with therapeutic potential.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.titleNatural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement
dc.typeJournal Article
dc.identifier.doi10.1038/ncomms14253
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.source.titleNature Communications
melbourne.source.volume8
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1187103
melbourne.contributor.authorDavidson, Sophia
dc.identifier.eissn2041-1723
melbourne.accessrightsOpen Access


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