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dc.contributor.authorTremblay, J
dc.contributor.authorWang, Y
dc.contributor.authorRaelson, J
dc.contributor.authorMarois-Blanchet, F-C
dc.contributor.authorWu, Z
dc.contributor.authorLuo, H
dc.contributor.authorBradley, E
dc.contributor.authorChalmers, J
dc.contributor.authorWoodward, M
dc.contributor.authorHarrap, S
dc.contributor.authorHamet, P
dc.contributor.authorWu, J
dc.date.accessioned2020-12-22T05:03:55Z
dc.date.available2020-12-22T05:03:55Z
dc.date.issued2017-03-08
dc.identifierpii: srep44114
dc.identifier.citationTremblay, J., Wang, Y., Raelson, J., Marois-Blanchet, F. -C., Wu, Z., Luo, H., Bradley, E., Chalmers, J., Woodward, M., Harrap, S., Hamet, P. & Wu, J. (2017). Evidence from single nucleotide polymorphism analyses of ADVANCE study demonstrates EFNB3 as a hypertension risk gene. SCIENTIFIC REPORTS, 7 (1), https://doi.org/10.1038/srep44114.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11343/258202
dc.description.abstractEPH kinases and their ligands, ephrins (EFNs), have vital and diverse biological functions. We recently reported that Efnb3 gene deletion results in hypertension in female but not male mice. These data suggest that EFNB3 regulates blood pressure in a sex- and sex hormone-dependent way. In the present study, we conducted a human genetic study to assess the association of EFNB3 single nucleotide polymorphisms with human hypertension risks, using 3,448 patients with type 2 diabetes from the ADVANCE study (Action in Diabetes and Vascular Disease: Peterax and Diamicron MR Controlled Evaluation). We have observed significant association between 2 SNPs in the 3' untranslated region or within the adjacent region just 3' of the EFNB3 gene with hypertension, corroborating our findings from the mouse model. Thus, our investigation has shown that EFNB3 is a hypertension risk gene in certain individuals.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleEvidence from single nucleotide polymorphism analyses of ADVANCE study demonstrates EFNB3 as a hypertension risk gene
dc.typeJournal Article
dc.identifier.doi10.1038/srep44114
melbourne.affiliation.departmentPhysiology
melbourne.source.titleScientific Reports
melbourne.source.volume7
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1191057
melbourne.contributor.authorHarrap, Stephen
dc.identifier.eissn2045-2322
melbourne.accessrightsOpen Access


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