The pre-existing population of 5S rRNA effects p53 stabilization during ribosome biogenesis inhibition
AuthorOnofrillo, C; Galbiati, A; Montanaro, L; Derenzini, M
PublisherIMPACT JOURNALS LLC
University of Melbourne Author/sOnofrillo, Carmine
AffiliationSurgery (St Vincent's)
Document TypeJournal Article
CitationsOnofrillo, C., Galbiati, A., Montanaro, L. & Derenzini, M. (2017). The pre-existing population of 5S rRNA effects p53 stabilization during ribosome biogenesis inhibition. ONCOTARGET, 8 (3), pp.4257-4267. https://doi.org/10.18632/oncotarget.13833.
Access StatusOpen Access
Pre-ribosomal complex RPL5/RPL11/5S rRNA (5S RNP) is considered the central MDM2 inhibitory complex that control p53 stabilization during ribosome biogenesis inhibition. Despite its role is well defined, the dynamic of 5S RNP assembly still requires further characterization. In the present work, we report that MDM2 inhibition is dependent by a pre-existing population of 5S rRNA.
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