The pre-existing population of 5S rRNA effects p53 stabilization during ribosome biogenesis inhibition

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    Author
    Onofrillo, C; Galbiati, A; Montanaro, L; Derenzini, M
    Date
    2017-01-17
    Source Title
    Oncotarget
    Publisher
    IMPACT JOURNALS LLC
    University of Melbourne Author/s
    Onofrillo, Carmine
    Affiliation
    Surgery (St Vincent's)
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    Document Type
    Journal Article
    Citations
    Onofrillo, C., Galbiati, A., Montanaro, L. & Derenzini, M. (2017). The pre-existing population of 5S rRNA effects p53 stabilization during ribosome biogenesis inhibition. ONCOTARGET, 8 (3), pp.4257-4267. https://doi.org/10.18632/oncotarget.13833.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/258203
    DOI
    10.18632/oncotarget.13833
    Abstract
    Pre-ribosomal complex RPL5/RPL11/5S rRNA (5S RNP) is considered the central MDM2 inhibitory complex that control p53 stabilization during ribosome biogenesis inhibition. Despite its role is well defined, the dynamic of 5S RNP assembly still requires further characterization. In the present work, we report that MDM2 inhibition is dependent by a pre-existing population of 5S rRNA.

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