Variation in the bovine FABP4 gene affects milk yield and milk protein content in dairy cows
AuthorZhou, H; Cheng, L; Azimu, W; Hodge, S; Edwards, GR; Hickford, JGH
Source TitleScientific Reports
PublisherNATURE PUBLISHING GROUP
University of Melbourne Author/sCheng, Long
AffiliationAgriculture and Food Systems
Document TypeJournal Article
CitationsZhou, H., Cheng, L., Azimu, W., Hodge, S., Edwards, G. R. & Hickford, J. G. H. (2015). Variation in the bovine FABP4 gene affects milk yield and milk protein content in dairy cows. SCIENTIFIC REPORTS, 5 (1), https://doi.org/10.1038/srep10023.
Access StatusOpen Access
Fatty acid binding proteins (FABPs) bind long-chain fatty acids and are involved in their intracellular transport. Of the known bovine FABP genes, FABP4 has been mapped to a region on chromosome 14 that contains quantitative trait loci for milk traits. This study investigated the association of FABP4 haplotypes with milk production traits in 719 Holstein-Friesian × Jersey cows. Polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) analysis of a variable region of the gene revealed three haplotypes (A, B and C). Five single nucleotide polymorphisms (SNPs) were identified: two in exon 3 and three in intron 3. A was associated (P=0.032) with increased milk protein percentage (present: 4.00 ± 0.02%; absent: 3.95 ± 0.02%) and B was associated (P=0.009) with increased milk yield (present: 23.81 ± 0.23 kg/d; absent: 23.06 ± 0.21 kg/d), but tended to be associated with a decrease in protein percentage and an increase in protein yield. Cows with genotypes AA, AB and AC produced less milk, but with a higher protein percentage than BC cows. This suggest that FABP4 affects milk yield and milk protein content, both economically important traits, and that further study of this gene is warranted.
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References