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dc.contributor.authorZhou, H
dc.contributor.authorCheng, L
dc.contributor.authorAzimu, W
dc.contributor.authorHodge, S
dc.contributor.authorEdwards, GR
dc.contributor.authorHickford, JGH
dc.date.accessioned2020-12-22T05:09:51Z
dc.date.available2020-12-22T05:09:51Z
dc.date.issued2015-06-12
dc.identifierpii: srep10023
dc.identifier.citationZhou, H., Cheng, L., Azimu, W., Hodge, S., Edwards, G. R. & Hickford, J. G. H. (2015). Variation in the bovine FABP4 gene affects milk yield and milk protein content in dairy cows. SCIENTIFIC REPORTS, 5 (1), https://doi.org/10.1038/srep10023.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11343/258225
dc.description.abstractFatty acid binding proteins (FABPs) bind long-chain fatty acids and are involved in their intracellular transport. Of the known bovine FABP genes, FABP4 has been mapped to a region on chromosome 14 that contains quantitative trait loci for milk traits. This study investigated the association of FABP4 haplotypes with milk production traits in 719 Holstein-Friesian × Jersey cows. Polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) analysis of a variable region of the gene revealed three haplotypes (A, B and C). Five single nucleotide polymorphisms (SNPs) were identified: two in exon 3 and three in intron 3. A was associated (P=0.032) with increased milk protein percentage (present: 4.00 ± 0.02%; absent: 3.95 ± 0.02%) and B was associated (P=0.009) with increased milk yield (present: 23.81 ± 0.23 kg/d; absent: 23.06 ± 0.21 kg/d), but tended to be associated with a decrease in protein percentage and an increase in protein yield. Cows with genotypes AA, AB and AC produced less milk, but with a higher protein percentage than BC cows. This suggest that FABP4 affects milk yield and milk protein content, both economically important traits, and that further study of this gene is warranted.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleVariation in the bovine FABP4 gene affects milk yield and milk protein content in dairy cows
dc.typeJournal Article
dc.identifier.doi10.1038/srep10023
melbourne.affiliation.departmentAgriculture and Food Systems
melbourne.source.titleScientific Reports
melbourne.source.volume5
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1189496
pubs.publisher-urlhttps://www.ncbi.nlm.nih.gov/pubmed/26067182
melbourne.contributor.authorCheng, Long
dc.identifier.eissn2045-2322
melbourne.accessrightsOpen Access


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