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dc.contributor.authorBaker, JE
dc.contributor.authorLim, YY
dc.contributor.authorPietrzak, RH
dc.contributor.authorHassenstab, J
dc.contributor.authorSnyder, PJ
dc.contributor.authorMasters, CL
dc.contributor.authorMaruff, P
dc.date.accessioned2020-12-22T05:12:17Z
dc.date.available2020-12-22T05:12:17Z
dc.date.issued2017
dc.identifierpii: S2352-8729(16)30047-1
dc.identifier.citationBaker, J. E., Lim, Y. Y., Pietrzak, R. H., Hassenstab, J., Snyder, P. J., Masters, C. L. & Maruff, P. (2017). Cognitive impairment and decline in cognitively normal older adults with high amyloid-β: A meta-analysis.. Alzheimers Dement (Amst), 6 (1), pp.108-121. https://doi.org/10.1016/j.dadm.2016.09.002.
dc.identifier.issn2352-8729
dc.identifier.urihttp://hdl.handle.net/11343/258233
dc.description.abstractINTRODUCTION: This meta-analysis aimed to characterize the nature and magnitude of amyloid (Aβ)-related cognitive impairment and decline in cognitively normal (CN) older individuals. METHOD: MEDLINE Ovid was searched from 2012 to June 2016 for studies reporting relationships between cerebrospinal fluid or positron emission tomography (PET) Aβ levels and cognitive impairment (cross-sectional) and decline (longitudinal) in CN older adults. Neuropsychological data were classified into domains of episodic memory, executive function, working memory, processing speed, visuospatial function, semantic memory, and global cognition. Type of Aβ measure, how Aβ burden was analyzed, inclusion of control variables, and clinical criteria used to exclude participants, were considered as moderators. Random-effects models were used for analyses with effect sizes expressed as Cohen's d. RESULTS: A total of 38 studies met inclusion criteria contributing 30 cross-sectional (N = 5005) and 14 longitudinal (N = 2584) samples. Aβ-related cognitive impairment was observed for global cognition (d = 0.32), visuospatial function (d = 0.25), processing speed (d = 0.18), episodic memory, and executive function (both d's = 0.15), with decline observed for global cognition (d = 0.30), semantic memory (d = 0.28), visuospatial function (d = 0.25), and episodic memory (d = 0.24). Aβ-related impairment was moderated by age, amyloid measure, type of analysis, and inclusion of control variables and decline moderated by amyloid measure, type of analysis, inclusion of control variables, and exclusion criteria used. DISCUSSION: CN older adults with high Aβ show a small general cognitive impairment and small to moderate decline in episodic memory, visuospatial function, semantic memory, and global cognition.
dc.languageeng
dc.publisherWiley
dc.titleCognitive impairment and decline in cognitively normal older adults with high amyloid-β: A meta-analysis.
dc.typeJournal Article
dc.identifier.doi10.1016/j.dadm.2016.09.002
melbourne.affiliation.departmentAnatomy and Neuroscience
melbourne.affiliation.departmentFlorey Department of Neuroscience and Mental Health
melbourne.source.titleAlzheimer's & dementia (Amsterdam, Netherlands)
melbourne.source.volume6
melbourne.source.issue1
melbourne.source.pages108-121
dc.rights.licenseCC BY-NC-ND
melbourne.elementsid1190346
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315443
melbourne.contributor.authorMaruff, Paul
melbourne.contributor.authorLim, Yen Ying
melbourne.contributor.authorMasters, Colin
dc.identifier.eissn2352-8729
melbourne.accessrightsOpen Access


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