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    Maternal-foetal transfer of Plasmodium falciparum and Plasmodium vivax antibodies in a low transmission setting

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    Author
    Charnaud, SC; McGready, R; Herten-Crabb, A; Powell, R; Guy, A; Langer, C; Richards, JS; Gilson, PR; Chotivanich, K; Tsuboi, T; ...
    Date
    2016-02-10
    Source Title
    Scientific Reports
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    Beeson, James; Simpson, Julie; Fowkes, Freya; Richards, Jack; Charnaud, Sarah
    Affiliation
    Medicine and Radiology
    Melbourne School of Population and Global Health
    Medical Biology (W.E.H.I.)
    Metadata
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    Document Type
    Journal Article
    Citations
    Charnaud, S. C., McGready, R., Herten-Crabb, A., Powell, R., Guy, A., Langer, C., Richards, J. S., Gilson, P. R., Chotivanich, K., Tsuboi, T., Narum, D. L., Pimanpanarak, M., Simpson, J. A., Beeson, J. G., Nosten, F. & Fowkes, F. J. I. (2016). Maternal-foetal transfer of Plasmodium falciparum and Plasmodium vivax antibodies in a low transmission setting. SCIENTIFIC REPORTS, 6 (1), https://doi.org/10.1038/srep20859.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/258249
    DOI
    10.1038/srep20859
    Abstract
    During pregnancy immunoglobulin G (IgG) antibodies are transferred from mother to neonate across the placenta. Studies in high transmission areas have shown transfer of P. falciparum-specific IgG, but the extent and factors influencing maternal-foetal transfer in low transmission areas co-endemic for both P. falciparum and P. vivax are unknown. Pregnant women were screened weekly for Plasmodium infection. Mother-neonate paired serum samples at delivery were tested for IgG to antigens from P. falciparum, P. vivax and other infectious diseases. Antibodies to malarial and non-malarial antigens were highly correlated between maternal and neonatal samples (median [range] spearman ρ = 0.78 [0.57-0.93]), although Plasmodium spp. antibodies tended to be lower in neonates than mothers. Estimated gestational age at last P. falciparum infection, but not P. vivax infection, was positively associated with antibody levels in the neonate (P. falciparum merozoite, spearman ρ median [range] 0.42 [0.33-0.66], PfVAR2CSA 0.69; P. vivax ρ = 0.19 [0.09-0.3]). Maternal-foetal transfer of anti-malarial IgG to Plasmodium spp. antigens occurs in low transmission settings. P. vivax IgG acquisition is not associated with recent exposure unlike P. falciparum IgG, suggesting a difference in acquisition of antibodies. IgG transfer is greatest in the final weeks of pregnancy which has implications for the timing of future malaria vaccination strategies in pregnant women.

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