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dc.contributor.authorde la Fuente, AG
dc.contributor.authorErrea, O
dc.contributor.authorvan Wijngaarden, P
dc.contributor.authorGonzalez, GA
dc.contributor.authorKerninon, C
dc.contributor.authorJarjour, AA
dc.contributor.authorLewis, HJ
dc.contributor.authorJones, CA
dc.contributor.authorNait-Oumesmar, B
dc.contributor.authorZhao, C
dc.contributor.authorHuang, JK
dc.contributor.authorFfrench-Constant, C
dc.contributor.authorFranklin, RJM
dc.date.accessioned2020-12-22T05:22:01Z
dc.date.available2020-12-22T05:22:01Z
dc.date.issued2015-12-07
dc.identifierpii: jcb.201505119
dc.identifier.citationde la Fuente, A. G., Errea, O., van Wijngaarden, P., Gonzalez, G. A., Kerninon, C., Jarjour, A. A., Lewis, H. J., Jones, C. A., Nait-Oumesmar, B., Zhao, C., Huang, J. K., Ffrench-Constant, C. & Franklin, R. J. M. (2015). Vitamin D receptor-retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation. JOURNAL OF CELL BIOLOGY, 211 (5), pp.975-985. https://doi.org/10.1083/jcb.201505119.
dc.identifier.issn0021-9525
dc.identifier.urihttp://hdl.handle.net/11343/258271
dc.description.abstractThe mechanisms regulating differentiation of oligodendrocyte (OLG) progenitor cells (OPCs) into mature OLGs are key to understanding myelination and remyelination. Signaling via the retinoid X receptor γ (RXR-γ) has been shown to be a positive regulator of OPC differentiation. However, the nuclear receptor (NR) binding partner of RXR-γ has not been established. In this study we show that RXR-γ binds to several NRs in OPCs and OLGs, one of which is vitamin D receptor (VDR). Using pharmacological and knockdown approaches we show that RXR-VDR signaling induces OPC differentiation and that VDR agonist vitamin D enhances OPC differentiation. We also show expression of VDR in OLG lineage cells in multiple sclerosis. Our data reveal a role for vitamin D in the regenerative component of demyelinating disease and identify a new target for remyelination medicines.
dc.languageEnglish
dc.publisherROCKEFELLER UNIV PRESS
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0
dc.titleVitamin D receptor-retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation
dc.typeJournal Article
dc.identifier.doi10.1083/jcb.201505119
melbourne.affiliation.departmentOphthalmology (Eye & Ear Hospital)
melbourne.source.titleThe Journal of Cell Biology
melbourne.source.volume211
melbourne.source.issue5
melbourne.source.pages975-985
melbourne.identifier.nhmrc628928
dc.rights.licenseCC BY-NC-SA
melbourne.elementsid1036241
melbourne.contributor.authorvan Wijngaarden, Peter
dc.identifier.eissn1540-8140
melbourne.identifier.fundernameidNHMRC, 628928
melbourne.accessrightsOpen Access


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