A WAO - ARIA - GA²LEN consensus document on molecular-based allergy diagnostics.
AuthorCanonica, GW; Ansotegui, IJ; Pawankar, R; Schmid-Grendelmeier, P; van Hage, M; Baena-Cagnani, CE; Melioli, G; Nunes, C; Passalacqua, G; Rosenwasser, L; ...
Source TitleThe World Allergy Organization Journal
University of Melbourne Author/sAllen, Katrina
Document TypeJournal Article
CitationsCanonica, G. W., Ansotegui, I. J., Pawankar, R., Schmid-Grendelmeier, P., van Hage, M., Baena-Cagnani, C. E., Melioli, G., Nunes, C., Passalacqua, G., Rosenwasser, L., Sampson, H., Sastre, J., Bousquet, J., Zuberbier, T. & WAO-ARIA-GA2LEN Task Force: Katrina Allen, Riccardo Asero, Barbara Bohle, Linda Cox, Frederic de Blay, Motohiro Ebisawa, Rene Maximiliano-Gomez, Sandra Gonzalez-Diaz, Tari Haahtela, Stephen Holgate, Thilo Jakob, Mark Larche, Paolo Maria Matricardi, John Oppenheimer, Lars K Poulsen, Harald E Renz, Nelson Rosario, Marc Rothenberg, Mario Sanchez-Borges, Enrico Scala, Rudolf Valenta, (2013). A WAO - ARIA - GA²LEN consensus document on molecular-based allergy diagnostics.. World Allergy Organ J, 6 (1), pp.17-. https://doi.org/10.1186/1939-4551-6-17.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874689
Molecular-based allergy (MA) diagnostics is an approach used to map the allergen sensitization of a patient at a molecular level, using purified natural or recombinant allergenic molecules (allergen components) instead of allergen extracts. Since its introduction, MA diagnostics has increasingly entered routine care, with currently more than 130 allergenic molecules commercially available for in vitro specific IgE (sIgE) testing.MA diagnostics allows for an increased accuracy in allergy diagnosis and prognosis and plays an important role in three key aspects of allergy diagnosis: (1) resolving genuine versus cross-reactive sensitization in poly-sensitized patients, thereby improving the understanding of triggering allergens; (2) assessing, in selected cases, the risk of severe, systemic versus mild, local reactions in food allergy, thereby reducing unnecessary anxiety for the patient and the need for food challenge testing; and (3) identifying patients and triggering allergens for specific immunotherapy (SIT).Singleplex and multiplex measurement platforms are available for MA diagnostics. The Immuno-Solid phase Allergen Chip (ISAC) is the most comprehensive platform currently available, which involves a biochip technology to measure sIgE antibodies against more than one hundred allergenic molecules in a single assay. As the field of MA diagnostics advances, future work needs to focus on large-scale, population-based studies involving practical applications, elucidation and expansion of additional allergenic molecules, and support for appropriate test interpretation. With the rapidly expanding evidence-base for MA diagnosis, there is a need for allergists to keep abreast of the latest information. The aim of this consensus document is to provide a practical guide for the indications, determination, and interpretation of MA diagnostics for clinicians trained in allergology.
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