Genomic characterisation of E mu-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene
AuthorLefebure, M; Tothill, RW; Kruse, E; Hawkins, ED; Shortt, J; Matthews, GM; Gregory, GP; Martin, BP; Kelly, MJ; Todorovski, I; ...
Source TitleNature Communications
PublisherNATURE PUBLISHING GROUP
University of Melbourne Author/sDoyle, Maria; Tothill, Richard; Shortt, Jake; Li, Jason; Poortinga, Gretchen; Kats, Lev; Hannan, Ross; Papenfuss, Anthony; Johnstone, Ricky; Hawkins, Edwin; ...
AffiliationComputing and Information Systems
Sir Peter MacCallum Department of Oncology
Medical Biology (W.E.H.I.)
Medicine (St Vincent's)
Document TypeJournal Article
CitationsLefebure, M., Tothill, R. W., Kruse, E., Hawkins, E. D., Shortt, J., Matthews, G. M., Gregory, G. P., Martin, B. P., Kelly, M. J., Todorovski, I., Doyle, M. A., Lupat, R., Li, J., Schroeder, J., Wall, M., Craig, S., Poortinga, G., Cameron, D., Bywater, M. ,... Johnstone, R. W. (2017). Genomic characterisation of E mu-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene. NATURE COMMUNICATIONS, 8 (1), pp.1-10. https://doi.org/10.1038/ncomms14581.
Access StatusOpen Access
The Eμ-Myc mouse is an extensively used model of MYC driven malignancy; however to date there has only been partial characterization of MYC co-operative mutations leading to spontaneous lymphomagenesis. Here we sequence spontaneously arising Eμ-Myc lymphomas to define transgene architecture, somatic mutations, and structural alterations. We identify frequent disruptive mutations in the PRC1-like component and BCL6-corepressor gene Bcor. Moreover, we find unexpected concomitant multigenic lesions involving Cdkn2a loss and other cancer genes including Nras, Kras and Bcor. These findings challenge the assumed two-hit model of Eμ-Myc lymphoma and demonstrate a functional in vivo role for Bcor in suppressing tumorigenesis.
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Publisher licenceCC BY
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