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dc.contributor.authorLefebure, M
dc.contributor.authorTothill, RW
dc.contributor.authorKruse, E
dc.contributor.authorHawkins, ED
dc.contributor.authorShortt, J
dc.contributor.authorMatthews, GM
dc.contributor.authorGregory, GP
dc.contributor.authorMartin, BP
dc.contributor.authorKelly, MJ
dc.contributor.authorTodorovski, I
dc.contributor.authorDoyle, MA
dc.contributor.authorLupat, R
dc.contributor.authorLi, J
dc.contributor.authorSchroeder, J
dc.contributor.authorWall, M
dc.contributor.authorCraig, S
dc.contributor.authorPoortinga, G
dc.contributor.authorCameron, D
dc.contributor.authorBywater, M
dc.contributor.authorKats, L
dc.contributor.authorGearhart, MD
dc.contributor.authorBardwell, VJ
dc.contributor.authorDickins, RA
dc.contributor.authorHannan, RD
dc.contributor.authorPapenfuss, AT
dc.contributor.authorJohnstone, RW
dc.date.accessioned2020-12-22T05:26:09Z
dc.date.available2020-12-22T05:26:09Z
dc.date.issued2017-03-06
dc.identifierpii: ncomms14581
dc.identifier.citationLefebure, M., Tothill, R. W., Kruse, E., Hawkins, E. D., Shortt, J., Matthews, G. M., Gregory, G. P., Martin, B. P., Kelly, M. J., Todorovski, I., Doyle, M. A., Lupat, R., Li, J., Schroeder, J., Wall, M., Craig, S., Poortinga, G., Cameron, D., Bywater, M. ,... Johnstone, R. W. (2017). Genomic characterisation of E mu-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene. NATURE COMMUNICATIONS, 8 (1), pp.1-10. https://doi.org/10.1038/ncomms14581.
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/11343/258287
dc.description.abstractThe Eμ-Myc mouse is an extensively used model of MYC driven malignancy; however to date there has only been partial characterization of MYC co-operative mutations leading to spontaneous lymphomagenesis. Here we sequence spontaneously arising Eμ-Myc lymphomas to define transgene architecture, somatic mutations, and structural alterations. We identify frequent disruptive mutations in the PRC1-like component and BCL6-corepressor gene Bcor. Moreover, we find unexpected concomitant multigenic lesions involving Cdkn2a loss and other cancer genes including Nras, Kras and Bcor. These findings challenge the assumed two-hit model of Eμ-Myc lymphoma and demonstrate a functional in vivo role for Bcor in suppressing tumorigenesis.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleGenomic characterisation of E mu-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene
dc.typeJournal Article
dc.identifier.doi10.1038/ncomms14581
melbourne.affiliation.departmentComputing and Information Systems
melbourne.affiliation.departmentSir Peter MacCallum Department of Oncology
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.affiliation.departmentBio21
melbourne.affiliation.departmentClinical Pathology
melbourne.affiliation.departmentMedicine (St Vincent's)
melbourne.affiliation.facultyEngineering and Information Technology
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.affiliation.facultyAffiliate
melbourne.source.titleNature Communications
melbourne.source.volume8
melbourne.source.issue1
melbourne.source.pages1-10
dc.rights.licenseCC BY
melbourne.elementsid1190635
melbourne.contributor.authorDoyle, Maria
melbourne.contributor.authorTothill, Richard
melbourne.contributor.authorShortt, Jake
melbourne.contributor.authorLi, Jason
melbourne.contributor.authorPoortinga, Gretchen
melbourne.contributor.authorKats, Lev
melbourne.contributor.authorHannan, Ross
melbourne.contributor.authorPapenfuss, Anthony
melbourne.contributor.authorJohnstone, Ricky
melbourne.contributor.authorHawkins, Edwin
melbourne.contributor.authorKruse, Elizabeth
melbourne.contributor.authorLefebure, Marcus
melbourne.contributor.authorGregory, Gareth
melbourne.contributor.authorCameron, Donald
melbourne.contributor.authorMatthews, Geoffrey
melbourne.contributor.authorWall, Meaghan
melbourne.contributor.authorSchroeder, Jan
melbourne.contributor.authorLupat, Richard
dc.identifier.eissn2041-1723
melbourne.accessrightsOpen Access


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