mTOR-sensitive translation: Cleared fog reveals more trees
AuthorMasvidal, L; Hulea, L; Furic, L; Topisirovic, I; Larsson, O
Source TitleRNA Biology
PublisherTAYLOR & FRANCIS INC
University of Melbourne Author/sFuric, Luc
AffiliationSir Peter MacCallum Department of Oncology
Document TypeJournal Article
CitationsMasvidal, L., Hulea, L., Furic, L., Topisirovic, I. & Larsson, O. (2017). mTOR-sensitive translation: Cleared fog reveals more trees. RNA BIOLOGY, 14 (10), pp.1299-1305. https://doi.org/10.1080/15476286.2017.1290041.
Access StatusOpen Access
Translation is fundamental for many biologic processes as it enables cells to rapidly respond to stimuli without requiring de novo mRNA synthesis. The mammalian/mechanistic target of rapamycin (mTOR) is a key regulator of translation. Although mTOR affects global protein synthesis, translation of a subset of mRNAs appears to be exceptionally sensitive to changes in mTOR activity. Recent efforts to catalog these mTOR-sensitive mRNAs resulted in conflicting results. Whereas ribosome-profiling almost exclusively identified 5'-terminal oligopyrimidine (TOP) mRNAs as mTOR-sensitive, polysome-profiling suggested that mTOR also regulates translation of non-TOP mRNAs. This inconsistency was explained by analytical and technical biases limiting the efficiency of ribosome-profiling in detecting mRNAs showing differential translation. Moreover, genome-wide characterization of 5'UTRs of non-TOP mTOR-sensitive mRNAs revealed 2 subsets of transcripts which differ in their requirement for translation initiation factors and biologic functions. We summarize these recent advances and their impact on the understanding of mTOR-sensitive translation.
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