University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Medicine and Radiology
  • Medicine and Radiology - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Medicine and Radiology
  • Medicine and Radiology - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria

    Thumbnail
    Download
    Published version (3.740Mb)

    Citations
    Scopus
    Web of Science
    Altmetric
    127
    119
    Author
    Beeson, JG; Drew, DR; Boyle, MJ; Feng, G; Fowkes, FJI; Richards, JS
    Date
    2016-05-01
    Source Title
    FEMS Microbiology Reviews
    Publisher
    OXFORD UNIV PRESS
    University of Melbourne Author/s
    Beeson, James; Fowkes, Freya; Richards, Jack; Feng, Gaoqian
    Affiliation
    Medicine and Radiology
    Melbourne School of Population and Global Health
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Beeson, J. G., Drew, D. R., Boyle, M. J., Feng, G., Fowkes, F. J. I. & Richards, J. S. (2016). Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria. FEMS MICROBIOLOGY REVIEWS, 40 (3), pp.343-372. https://doi.org/10.1093/femsre/fuw001.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/258332
    DOI
    10.1093/femsre/fuw001
    Abstract
    Malaria accounts for an enormous burden of disease globally, with Plasmodium falciparum accounting for the majority of malaria, and P. vivax being a second important cause, especially in Asia, the Americas and the Pacific. During infection with Plasmodium spp., the merozoite form of the parasite invades red blood cells and replicates inside them. It is during the blood-stage of infection that malaria disease occurs and, therefore, understanding merozoite invasion, host immune responses to merozoite surface antigens, and targeting merozoite surface proteins and invasion ligands by novel vaccines and therapeutics have been important areas of research. Merozoite invasion involves multiple interactions and events, and substantial processing of merozoite surface proteins occurs before, during and after invasion. The merozoite surface is highly complex, presenting a multitude of antigens to the immune system. This complexity has proved challenging to our efforts to understand merozoite invasion and malaria immunity, and to developing merozoite antigens as malaria vaccines. In recent years, there has been major progress in this field, and several merozoite surface proteins show strong potential as malaria vaccines. Our current knowledge on this topic is reviewed, highlighting recent advances and research priorities.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [53039]
    • Melbourne School of Population and Global Health - Research Publications [5329]
    • Medicine and Radiology - Research Publications [3320]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors