University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Medical Bionics
  • Medical Bionics - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Medical Bionics
  • Medical Bionics - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Functional Connectivity of the Pedunculopontine Nucleus and Surrounding Region in Parkinson's Disease

    Thumbnail
    Download
    Published version (566.0Kb)

    Citations
    Scopus
    Web of Science
    Altmetric
    11
    11
    Author
    Jha, A; Litvak, V; Taulu, S; Thevathasan, W; Hyam, JA; Foltynie, T; Limousin, P; Bogdanovic, M; Zrinzo, L; Green, AL; ...
    Date
    2017-01-01
    Source Title
    Cerebral Cortex
    Publisher
    OXFORD UNIV PRESS INC
    University of Melbourne Author/s
    Thevathasan, Wesley
    Affiliation
    Medical Bionics
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Jha, A., Litvak, V., Taulu, S., Thevathasan, W., Hyam, J. A., Foltynie, T., Limousin, P., Bogdanovic, M., Zrinzo, L., Green, A. L., Aziz, T. Z., Friston, K. & Brown, P. (2017). Functional Connectivity of the Pedunculopontine Nucleus and Surrounding Region in Parkinson's Disease. CEREBRAL CORTEX, 27 (1), pp.54-67. https://doi.org/10.1093/cercor/bhw340.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/258351
    DOI
    10.1093/cercor/bhw340
    Abstract
    Deep brain stimulation of the pedunculopontine nucleus and surrounding region (PPNR) is a novel treatment strategy for gait freezing in Parkinson's disease (PD). However, clinical results have been variable, in part because of the paucity of functional information that might help guide selection of the optimal surgical target. In this study, we use simultaneous magnetoencephalography and local field recordings from the PPNR in seven PD patients, to characterize functional connectivity with distant brain areas at rest. The PPNR was preferentially coupled to brainstem and cingulate regions in the alpha frequency (8-12 Hz) band and to the medial motor strip and neighboring areas in the beta (18-33 Hz) band. The distribution of coupling also depended on the vertical distance of the electrode from the pontomesencephalic line: most effects being greatest in the middle PPNR, which may correspond to the caudal pars dissipata of the pedunculopontine nucleus. These observations confirm the crucial position of the PPNR as a functional node between cortical areas such as the cingulate/ medial motor strip and other brainstem nuclei, particularly in the dorsal pons. In particular they suggest a special role for the middle PPNR as this has the greatest functional connectivity with other brain regions.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [45770]
    • Medical Bionics - Research Publications [77]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors