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dc.contributor.authorMcIntosh, RS
dc.contributor.authorShi, J
dc.contributor.authorJennings, RM
dc.contributor.authorChappel, JC
dc.contributor.authorde Koning-Ward, TF
dc.contributor.authorSmith, T
dc.contributor.authorGreen, J
dc.contributor.authorvan Egmond, M
dc.contributor.authorLeusen, JHW
dc.contributor.authorLazarou, M
dc.contributor.authorvan de Winkel, J
dc.contributor.authorJones, TS
dc.contributor.authorCrabb, BS
dc.contributor.authorHolder, AA
dc.contributor.authorPleass, RJ
dc.date.accessioned2020-12-22T05:48:55Z
dc.date.available2020-12-22T05:48:55Z
dc.date.issued2007-05-01
dc.identifierpii: 07-PLPA-RA-0042R2
dc.identifier.citationMcIntosh, R. S., Shi, J., Jennings, R. M., Chappel, J. C., de Koning-Ward, T. F., Smith, T., Green, J., van Egmond, M., Leusen, J. H. W., Lazarou, M., van de Winkel, J., Jones, T. S., Crabb, B. S., Holder, A. A. & Pleass, R. J. (2007). The importance of human Fc gamma RI in mediating protection to malaria. PLOS PATHOGENS, 3 (5), pp.647-658. https://doi.org/10.1371/journal.ppat.0030072.
dc.identifier.issn1553-7366
dc.identifier.urihttp://hdl.handle.net/11343/258362
dc.description.abstractThe success of passive immunization suggests that antibody-based therapies will be effective at controlling malaria. We describe the development of fully human antibodies specific for Plasmodium falciparum by antibody repertoire cloning from phage display libraries generated from immune Gambian adults. Although these novel reagents bind with strong affinity to malaria parasites, it remains unclear if in vitro assays are predictive of functional immunity in humans, due to the lack of suitable animal models permissive for P. falciparum. A potentially useful solution described herein allows the antimalarial efficacy of human antibodies to be determined using rodent malaria parasites transgenic for P. falciparum antigens in mice also transgenic for human Fc-receptors. These human IgG1s cured animals of an otherwise lethal malaria infection, and protection was crucially dependent on human FcgammaRI. This important finding documents the capacity of FcgammaRI to mediate potent antimalaria immunity and supports the development of FcgammaRI-directed therapy for human malaria.
dc.languageEnglish
dc.publisherPUBLIC LIBRARY SCIENCE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleThe importance of human Fc gamma RI in mediating protection to malaria
dc.typeJournal Article
dc.identifier.doi10.1371/journal.ppat.0030072
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.source.titlePLoS Pathogens
melbourne.source.volume3
melbourne.source.issue5
melbourne.source.pages647-658
dc.rights.licenseCC BY
melbourne.elementsid1194793
melbourne.contributor.authorCrabb, Brendan
dc.identifier.eissn1553-7374
melbourne.accessrightsOpen Access


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