A SEARCH FOR MESSENGER-RNA MOLECULES BEARING IMMUNOGLOBULIN VH NUCLEOTIDE-SEQUENCES IN T-CELLS
Web of Science
AuthorKEMP, DJ; ADAMS, JM; MOTTRAM, PL; THOMAS, WR; WALKER, ID; MILLER, J
Source TitleJournal of Experimental Medicine
PublisherROCKEFELLER UNIV PRESS
University of Melbourne Author/sAdams, Jerry
AffiliationMedical Biology (W.E.H.I.)
Document TypeJournal Article
CitationsKEMP, D. J., ADAMS, J. M., MOTTRAM, P. L., THOMAS, W. R., WALKER, I. D. & MILLER, J. (1982). A SEARCH FOR MESSENGER-RNA MOLECULES BEARING IMMUNOGLOBULIN VH NUCLEOTIDE-SEQUENCES IN T-CELLS. JOURNAL OF EXPERIMENTAL MEDICINE, 156 (6), pp.1848-1853. https://doi.org/10.1084/jem.156.6.1848.
Access StatusOpen Access
Expression of VH-coded mRNA molecules in T cells, antigen-specific T cell lines, or T cell hybridomas was not detected using four different VH DNA probes under conditions that permitted cross-hybridization between distantly related VH genes. In contrast, VH gene expression was readily detected in two B cell lymphomas and in splenic B cells. Less than one molecule per cell of RNA, exactly complementary to the DNA probes used, would have been detected in these T cell populations. The results thus seriously question the proposition that T cells use the B cell VH repertoire to code for antigen receptors.
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