Show simple item record

dc.contributor.authorKEMP, DJ
dc.contributor.authorADAMS, JM
dc.contributor.authorMOTTRAM, PL
dc.contributor.authorTHOMAS, WR
dc.contributor.authorWALKER, ID
dc.contributor.authorMILLER, J
dc.date.accessioned2020-12-22T05:49:44Z
dc.date.available2020-12-22T05:49:44Z
dc.date.issued1982-01-01
dc.identifier.citationKEMP, D. J., ADAMS, J. M., MOTTRAM, P. L., THOMAS, W. R., WALKER, I. D. & MILLER, J. (1982). A SEARCH FOR MESSENGER-RNA MOLECULES BEARING IMMUNOGLOBULIN VH NUCLEOTIDE-SEQUENCES IN T-CELLS. JOURNAL OF EXPERIMENTAL MEDICINE, 156 (6), pp.1848-1853. https://doi.org/10.1084/jem.156.6.1848.
dc.identifier.issn0022-1007
dc.identifier.urihttp://hdl.handle.net/11343/258364
dc.description.abstractExpression of VH-coded mRNA molecules in T cells, antigen-specific T cell lines, or T cell hybridomas was not detected using four different VH DNA probes under conditions that permitted cross-hybridization between distantly related VH genes. In contrast, VH gene expression was readily detected in two B cell lymphomas and in splenic B cells. Less than one molecule per cell of RNA, exactly complementary to the DNA probes used, would have been detected in these T cell populations. The results thus seriously question the proposition that T cells use the B cell VH repertoire to code for antigen receptors.
dc.languageEnglish
dc.publisherROCKEFELLER UNIV PRESS
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0
dc.titleA SEARCH FOR MESSENGER-RNA MOLECULES BEARING IMMUNOGLOBULIN VH NUCLEOTIDE-SEQUENCES IN T-CELLS
dc.typeJournal Article
dc.identifier.doi10.1084/jem.156.6.1848
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.source.titleJournal of Experimental Medicine
melbourne.source.volume156
melbourne.source.issue6
melbourne.source.pages1848-1853
dc.rights.licenseCC BY-NC-SA
melbourne.elementsid1195233
melbourne.contributor.authorAdams, Jerry
dc.identifier.eissn1540-9538
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record