Activation of Latent Human Immunodeficiency Virus by the Histone Deacetylase Inhibitor Panobinostat: A Pilot Study to Assess Effects on the Central Nervous System
AuthorRasmussen, TA; Tolstrup, M; Moller, HJ; Brinkmann, CR; Olesen, R; Erikstrup, C; Laursen, AL; Ostergaard, L; Sogaard, OS
Source TitleOpen Forum Infectious Diseases
PublisherOXFORD UNIV PRESS INC
University of Melbourne Author/sRasmussen, Thomas
Document TypeJournal Article
CitationsRasmussen, T. A., Tolstrup, M., Moller, H. J., Brinkmann, C. R., Olesen, R., Erikstrup, C., Laursen, A. L., Ostergaard, L. & Sogaard, O. S. (2015). Activation of Latent Human Immunodeficiency Virus by the Histone Deacetylase Inhibitor Panobinostat: A Pilot Study to Assess Effects on the Central Nervous System. OPEN FORUM INFECTIOUS DISEASES, 2 (1), https://doi.org/10.1093/ofid/ofv037.
Access StatusOpen Access
In a substudy of a clinical trial, we assessed whether activation of latent human immunodeficiency virus (HIV) by the histone deacetylase inhibitor panobinostat had detrimental effects on the central nervous system (CNS). Adults infected with HIV received oral panobinostat 20 mg 3 times per week every other week for 8 weeks. In cerebrospinal fluid (CSF), we assayed panobinostat concentration, HIV RNA, and the level of neuroinflammatory or degenerative biomarkers in 11 individuals before and during study therapy. Neither panobinostat nor HIV RNA was detected in CSF. In addition, there was no change from baseline in CSF biomarkers. Thus, panobinostat administration was not associated with CNS adverse effects as assessed by CSF biomarkers.
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