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    Activation of Latent Human Immunodeficiency Virus by the Histone Deacetylase Inhibitor Panobinostat: A Pilot Study to Assess Effects on the Central Nervous System

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    Author
    Rasmussen, TA; Tolstrup, M; Moller, HJ; Brinkmann, CR; Olesen, R; Erikstrup, C; Laursen, AL; Ostergaard, L; Sogaard, OS
    Date
    2015-12-01
    Source Title
    Open Forum Infectious Diseases
    Publisher
    OXFORD UNIV PRESS INC
    University of Melbourne Author/s
    Rasmussen, Thomas
    Affiliation
    Doherty Institute
    Metadata
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    Document Type
    Journal Article
    Citations
    Rasmussen, T. A., Tolstrup, M., Moller, H. J., Brinkmann, C. R., Olesen, R., Erikstrup, C., Laursen, A. L., Ostergaard, L. & Sogaard, O. S. (2015). Activation of Latent Human Immunodeficiency Virus by the Histone Deacetylase Inhibitor Panobinostat: A Pilot Study to Assess Effects on the Central Nervous System. OPEN FORUM INFECTIOUS DISEASES, 2 (1), https://doi.org/10.1093/ofid/ofv037.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/258367
    DOI
    10.1093/ofid/ofv037
    Abstract
    In a substudy of a clinical trial, we assessed whether activation of latent human immunodeficiency virus (HIV) by the histone deacetylase inhibitor panobinostat had detrimental effects on the central nervous system (CNS). Adults infected with HIV received oral panobinostat 20 mg 3 times per week every other week for 8 weeks. In cerebrospinal fluid (CSF), we assayed panobinostat concentration, HIV RNA, and the level of neuroinflammatory or degenerative biomarkers in 11 individuals before and during study therapy. Neither panobinostat nor HIV RNA was detected in CSF. In addition, there was no change from baseline in CSF biomarkers. Thus, panobinostat administration was not associated with CNS adverse effects as assessed by CSF biomarkers.

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