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dc.contributor.authorRasmussen, TA
dc.contributor.authorTolstrup, M
dc.contributor.authorMoller, HJ
dc.contributor.authorBrinkmann, CR
dc.contributor.authorOlesen, R
dc.contributor.authorErikstrup, C
dc.contributor.authorLaursen, AL
dc.contributor.authorOstergaard, L
dc.contributor.authorSogaard, OS
dc.date.accessioned2020-12-22T05:50:31Z
dc.date.available2020-12-22T05:50:31Z
dc.date.issued2015-12-01
dc.identifierpii: ofv037
dc.identifier.citationRasmussen, T. A., Tolstrup, M., Moller, H. J., Brinkmann, C. R., Olesen, R., Erikstrup, C., Laursen, A. L., Ostergaard, L. & Sogaard, O. S. (2015). Activation of Latent Human Immunodeficiency Virus by the Histone Deacetylase Inhibitor Panobinostat: A Pilot Study to Assess Effects on the Central Nervous System. OPEN FORUM INFECTIOUS DISEASES, 2 (1), https://doi.org/10.1093/ofid/ofv037.
dc.identifier.issn2328-8957
dc.identifier.urihttp://hdl.handle.net/11343/258367
dc.description.abstractIn a substudy of a clinical trial, we assessed whether activation of latent human immunodeficiency virus (HIV) by the histone deacetylase inhibitor panobinostat had detrimental effects on the central nervous system (CNS). Adults infected with HIV received oral panobinostat 20 mg 3 times per week every other week for 8 weeks. In cerebrospinal fluid (CSF), we assayed panobinostat concentration, HIV RNA, and the level of neuroinflammatory or degenerative biomarkers in 11 individuals before and during study therapy. Neither panobinostat nor HIV RNA was detected in CSF. In addition, there was no change from baseline in CSF biomarkers. Thus, panobinostat administration was not associated with CNS adverse effects as assessed by CSF biomarkers.
dc.languageEnglish
dc.publisherOXFORD UNIV PRESS INC
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titleActivation of Latent Human Immunodeficiency Virus by the Histone Deacetylase Inhibitor Panobinostat: A Pilot Study to Assess Effects on the Central Nervous System
dc.typeJournal Article
dc.identifier.doi10.1093/ofid/ofv037
melbourne.affiliation.departmentDoherty Institute
melbourne.source.titleOpen Forum Infectious Diseases
melbourne.source.volume2
melbourne.source.issue1
dc.rights.licenseCC BY-NC-ND
melbourne.elementsid1195924
melbourne.contributor.authorRasmussen, Thomas
dc.identifier.eissn2328-8957
melbourne.accessrightsOpen Access


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