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    Circulating tumour DNA reflects treatment response and clonal evolution in chronic lymphocytic leukaemia

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    Author
    Yeh, P; Hunter, T; Sinha, D; Ftouni, S; Wallach, E; Jiang, D; Chan, Y-C; Wong, SQ; Silva, MJ; Vedururu, R; ...
    Date
    2017-03-17
    Source Title
    Nature Communications
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    Dawson, Mark; Lam, Enid; Westerman, David; Seymour, John; Papenfuss, Anthony; Tam, Constantine; Dawson, Sarah-Jane; Agarwal, Rishu; Yeh, Paul Sung-Hao; Hunter, Tane Alexander; ...
    Affiliation
    Medicine and Radiology
    Medical Biology (W.E.H.I.)
    Sir Peter MacCallum Department of Oncology
    Metadata
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    Document Type
    Journal Article
    Citations
    Yeh, P., Hunter, T., Sinha, D., Ftouni, S., Wallach, E., Jiang, D., Chan, Y. -C., Wong, S. Q., Silva, M. J., Vedururu, R., Doig, K., Lam, E., Arnau, G. M., Semple, T., Wall, M., Zivanovic, A., Agarwal, R., Petrone, P., Jones, K. ,... Dawson, S. -J. (2017). Circulating tumour DNA reflects treatment response and clonal evolution in chronic lymphocytic leukaemia. NATURE COMMUNICATIONS, 8 (1), https://doi.org/10.1038/ncomms14756.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/258382
    DOI
    10.1038/ncomms14756
    NHMRC Grant code
    NHMRC/1104549
    Abstract
    Several novel therapeutics are poised to change the natural history of chronic lymphocytic leukaemia (CLL) and the increasing use of these therapies has highlighted limitations of traditional disease monitoring methods. Here we demonstrate that circulating tumour DNA (ctDNA) is readily detectable in patients with CLL. Importantly, ctDNA does not simply mirror the genomic information contained within circulating malignant lymphocytes but instead parallels changes across different disease compartments following treatment with novel therapies. Serial ctDNA analysis allows clonal dynamics to be monitored over time and identifies the emergence of genomic changes associated with Richter's syndrome (RS). In addition to conventional disease monitoring, ctDNA provides a unique opportunity for non-invasive serial analysis of CLL for molecular disease monitoring.

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