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dc.contributor.authorYeh, P
dc.contributor.authorHunter, T
dc.contributor.authorSinha, D
dc.contributor.authorFtouni, S
dc.contributor.authorWallach, E
dc.contributor.authorJiang, D
dc.contributor.authorChan, Y-C
dc.contributor.authorWong, SQ
dc.contributor.authorSilva, MJ
dc.contributor.authorVedururu, R
dc.contributor.authorDoig, K
dc.contributor.authorLam, E
dc.contributor.authorArnau, GM
dc.contributor.authorSemple, T
dc.contributor.authorWall, M
dc.contributor.authorZivanovic, A
dc.contributor.authorAgarwal, R
dc.contributor.authorPetrone, P
dc.contributor.authorJones, K
dc.contributor.authorWesterman, D
dc.contributor.authorBlombery, P
dc.contributor.authorSeymour, JF
dc.contributor.authorPapenfuss, AT
dc.contributor.authorDawson, MA
dc.contributor.authorTam, CS
dc.contributor.authorDawson, S-J
dc.date.accessioned2020-12-22T05:54:13Z
dc.date.available2020-12-22T05:54:13Z
dc.date.issued2017-03-17
dc.identifierpii: ncomms14756
dc.identifier.citationYeh, P., Hunter, T., Sinha, D., Ftouni, S., Wallach, E., Jiang, D., Chan, Y. -C., Wong, S. Q., Silva, M. J., Vedururu, R., Doig, K., Lam, E., Arnau, G. M., Semple, T., Wall, M., Zivanovic, A., Agarwal, R., Petrone, P., Jones, K. ,... Dawson, S. -J. (2017). Circulating tumour DNA reflects treatment response and clonal evolution in chronic lymphocytic leukaemia. NATURE COMMUNICATIONS, 8 (1), https://doi.org/10.1038/ncomms14756.
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/11343/258382
dc.description.abstractSeveral novel therapeutics are poised to change the natural history of chronic lymphocytic leukaemia (CLL) and the increasing use of these therapies has highlighted limitations of traditional disease monitoring methods. Here we demonstrate that circulating tumour DNA (ctDNA) is readily detectable in patients with CLL. Importantly, ctDNA does not simply mirror the genomic information contained within circulating malignant lymphocytes but instead parallels changes across different disease compartments following treatment with novel therapies. Serial ctDNA analysis allows clonal dynamics to be monitored over time and identifies the emergence of genomic changes associated with Richter's syndrome (RS). In addition to conventional disease monitoring, ctDNA provides a unique opportunity for non-invasive serial analysis of CLL for molecular disease monitoring.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleCirculating tumour DNA reflects treatment response and clonal evolution in chronic lymphocytic leukaemia
dc.typeJournal Article
dc.identifier.doi10.1038/ncomms14756
melbourne.affiliation.departmentSir Peter MacCallum Department of Oncology
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.affiliation.departmentMedicine (St Vincent's)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleNature Communications
melbourne.source.volume8
melbourne.source.issue1
melbourne.identifier.nhmrc1104549
dc.rights.licenseCC BY
melbourne.elementsid1192867
melbourne.contributor.authorDawson, Mark
melbourne.contributor.authorLam, Enid
melbourne.contributor.authorWesterman, David
melbourne.contributor.authorSeymour, John
melbourne.contributor.authorPapenfuss, Anthony
melbourne.contributor.authorTam, Constantine
melbourne.contributor.authorDawson, Sarah-Jane
melbourne.contributor.authorAgarwal, Rishu
melbourne.contributor.authorYeh, Paul Sung-Hao
melbourne.contributor.authorHunter, Tane Alexander
melbourne.contributor.authorDoig, Kenneth
melbourne.contributor.authorWall, Meaghan
melbourne.contributor.authorZivanovic, Andjelija
melbourne.contributor.authorChan, Yih-Chih
dc.identifier.eissn2041-1723
melbourne.identifier.fundernameidNHMRC, 1104549
melbourne.accessrightsOpen Access


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