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dc.contributor.authorCastro-Hernandez, J
dc.contributor.authorAdlard, PA
dc.contributor.authorFinkelstein, DI
dc.date.accessioned2020-12-22T05:54:35Z
dc.date.available2020-12-22T05:54:35Z
dc.date.issued2017-03-14
dc.identifierpii: srep44426
dc.identifier.citationCastro-Hernandez, J., Adlard, P. A. & Finkelstein, D. I. (2017). Pramipexole restores depressed transmission in the ventral hippocampus following MPTP-lesion. SCIENTIFIC REPORTS, 7 (1), https://doi.org/10.1038/srep44426.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11343/258383
dc.description.abstractThe hippocampus has a significant association with memory, cognition and emotions. The dopaminergic projections from both the ventral tegmental area and substantia nigra are thought to be involved in hippocampal activity. To date, however, few studies have investigated dopaminergic innervation in the hippocampus or the functional consequences of reduced dopamine in disease models. Further complicating this, the hippocampus exhibits anatomical and functional differentiation along its dorso-ventral axis. In this work we investigated the role of dopamine on hippocampal long term potentiation using D-amphetamine, which stimulates dopamine release, and also examined how a dopaminergic lesion affects the synaptic transmission across the anatomic subdivisions of the hippocampus. Our findings indicate that a 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine induced dopaminergic lesion has time-dependent effects and impacts mainly on the ventral region of the hippocampus, consistent with the density of dopaminergic innervation. Treatment with a preferential D3 receptor agonist pramipexole partly restored normal synaptic transmission and Long-Term Potentiation. These data suggest a new mechanism to explain some of the actions of pramipexole in Parkinson´s disease.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titlePramipexole restores depressed transmission in the ventral hippocampus following MPTP-lesion
dc.typeJournal Article
dc.identifier.doi10.1038/srep44426
melbourne.affiliation.departmentFlorey Department of Neuroscience and Mental Health
melbourne.source.titleScientific Reports
melbourne.source.volume7
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1193079
melbourne.contributor.authorFinkelstein, David
melbourne.contributor.authorAdlard, Paul
dc.identifier.eissn2045-2322
melbourne.accessrightsOpen Access


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