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Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

dc.contributor.authorBerndt, SI
dc.contributor.authorCamp, NJ
dc.contributor.authorSkibola, CF
dc.contributor.authorVijai, J
dc.contributor.authorWang, Z
dc.contributor.authorGu, J
dc.contributor.authorNieters, A
dc.contributor.authorKelly, RS
dc.contributor.authorSmedby, KE
dc.contributor.authorMonnereau, A
dc.contributor.authorCozen, W
dc.contributor.authorCox, A
dc.contributor.authorWang, SS
dc.contributor.authorLan, Q
dc.contributor.authorTeras, LR
dc.contributor.authorMachado, M
dc.contributor.authorYeager, M
dc.contributor.authorBrooks-Wilson, AR
dc.contributor.authorHartge, P
dc.contributor.authorPurdue, MP
dc.contributor.authorBirmann, BM
dc.contributor.authorVajdic, CM
dc.contributor.authorCocco, P
dc.contributor.authorZhang, Y
dc.contributor.authorGiles, GG
dc.contributor.authorZeleniuch-Jacquotte, A
dc.contributor.authorLawrence, C
dc.contributor.authorMontalvan, R
dc.contributor.authorBurdett, L
dc.contributor.authorHutchinson, A
dc.contributor.authorYe, Y
dc.contributor.authorCall, TG
dc.contributor.authorShanafelt, TD
dc.contributor.authorNovak, AJ
dc.contributor.authorKay, NE
dc.contributor.authorLiebow, M
dc.contributor.authorCunningham, JM
dc.contributor.authorAllmer, C
dc.contributor.authorHjalgrim, H
dc.contributor.authorAdami, H-O
dc.contributor.authorMelbye, M
dc.contributor.authorGlimelius, B
dc.contributor.authorChang, ET
dc.contributor.authorGlenn, M
dc.contributor.authorCurtin, K
dc.contributor.authorCannon-Albright, LA
dc.contributor.authorDiver, WR
dc.contributor.authorLink, BK
dc.contributor.authorWeiner, GJ
dc.contributor.authorConde, L
dc.contributor.authorBracci, PM
dc.contributor.authorRiby, J
dc.contributor.authorArnett, DK
dc.contributor.authorZhi, D
dc.contributor.authorLeach, JM
dc.contributor.authorHolly, EA
dc.contributor.authorJackson, RD
dc.contributor.authorTinker, LF
dc.contributor.authorBenavente, Y
dc.contributor.authorSala, N
dc.contributor.authorCasabonne, D
dc.contributor.authorBecker, N
dc.contributor.authorBoffetta, P
dc.contributor.authorBrennan, P
dc.contributor.authorForetova, L
dc.contributor.authorMaynadie, M
dc.contributor.authorMcKay, J
dc.contributor.authorStaines, A
dc.contributor.authorChaffee, KG
dc.contributor.authorAchenbach, SJ
dc.contributor.authorVachon, CM
dc.contributor.authorGoldin, LR
dc.contributor.authorStrom, SS
dc.contributor.authorLeis, JF
dc.contributor.authorWeinberg, JB
dc.contributor.authorCaporaso, NE
dc.contributor.authorNorman, AD
dc.contributor.authorDe Roos, AJ
dc.contributor.authorMorton, LM
dc.contributor.authorSeverson, RK
dc.contributor.authorRiboli, E
dc.contributor.authorVineis, P
dc.contributor.authorKaaks, R
dc.contributor.authorMasala, G
dc.contributor.authorWeiderpass, E
dc.contributor.authorChirlaque, M-D
dc.contributor.authorVermeulen, RCH
dc.contributor.authorTravis, RC
dc.contributor.authorSouthey, MC
dc.contributor.authorMilne, RL
dc.contributor.authorAlbanese, D
dc.contributor.authorVirtamo, J
dc.contributor.authorWeinstein, S
dc.contributor.authorClavel, J
dc.contributor.authorZheng, T
dc.contributor.authorHolford, TR
dc.contributor.authorVillano, DJ
dc.contributor.authorMaria, A
dc.contributor.authorSpinelli, JJ
dc.contributor.authorGascoyne, RD
dc.contributor.authorConnors, JM
dc.contributor.authorBertrand, KA
dc.contributor.authorGiovannucci, E
dc.contributor.authorKraft, P
dc.contributor.authorKricker, A
dc.contributor.authorTurner, J
dc.contributor.authorEnnas, MG
dc.contributor.authorFerri, GM
dc.contributor.authorMiligi, L
dc.contributor.authorLiang, L
dc.contributor.authorMa, B
dc.contributor.authorHuang, J
dc.contributor.authorCrouch, S
dc.contributor.authorPark, J-H
dc.contributor.authorChatterjee, N
dc.contributor.authorNorth, KE
dc.contributor.authorSnowden, JA
dc.contributor.authorWright, J
dc.contributor.authorFraumeni, JF
dc.contributor.authorOffit, K
dc.contributor.authorWu, X
dc.contributor.authorde Sanjose, S
dc.contributor.authorCerhan, JR
dc.contributor.authorChanock, SJ
dc.contributor.authorRothman, N
dc.contributor.authorSlager, SL
dc.date.accessioned2020-12-22T05:59:49Z
dc.date.available2020-12-22T05:59:49Z
dc.date.issued2016-03-01
dc.identifierpii: ncomms10933
dc.identifier.citationBerndt, S. I., Camp, N. J., Skibola, C. F., Vijai, J., Wang, Z., Gu, J., Nieters, A., Kelly, R. S., Smedby, K. E., Monnereau, A., Cozen, W., Cox, A., Wang, S. S., Lan, Q., Teras, L. R., Machado, M., Yeager, M., Brooks-Wilson, A. R., Hartge, P. ,... Slager, S. L. (2016). Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. NATURE COMMUNICATIONS, 7 (1), https://doi.org/10.1038/ncomms10933.
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/11343/258402
dc.description.abstractChronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P=2.55 × 10(-11)), 6p25.2 (rs73718779, SERPINB6, P=1.97 × 10(-8)) and 3q28 (rs9815073, LPP, P=3.62 × 10(-8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P=1.00 × 10(-11)) in the combined analysis. We find suggestive evidence (P<5 × 10(-7)) for two additional new loci at 4q24 (rs10028805, BANK1, P=7.19 × 10(-8)) and 3p22.2 (rs1274963, CSRNP1, P=2.12 × 10(-7)). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.titleMeta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia
dc.typeJournal Article
dc.identifier.doi10.1038/ncomms10933
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.affiliation.departmentClinical Pathology
melbourne.source.titleNature Communications
melbourne.source.volume7
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1041549
melbourne.contributor.authorSouthey, Melissa
melbourne.contributor.authorGiles, Graham
melbourne.contributor.authorMilne, Roger
dc.identifier.eissn2041-1723
melbourne.accessrightsOpen Access


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