University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Science
  • School of BioSciences
  • School of BioSciences - Research Publications
  • View Item
  • Minerva Access
  • Science
  • School of BioSciences
  • School of BioSciences - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Mitochondrial DNA variants help monitor the dynamics of Wolbachia invasion into host populations

    Thumbnail
    Download
    Published version (1.678Mb)

    Citations
    Scopus
    Web of Science
    Altmetric
    16
    15
    Author
    Yeap, HL; Rasic, G; Endersby-Harshman, NM; Lee, SF; Arguni, E; Le Nguyen, H; Hoffmann, AA
    Date
    2016-03-01
    Source Title
    Heredity
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    RASIC, GORDANA; Endersby, Nancy; LEE, SIU; Hoffmann, Ary; Yeap, Heng Lin
    Affiliation
    School of BioSciences
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Yeap, H. L., Rasic, G., Endersby-Harshman, N. M., Lee, S. F., Arguni, E., Le Nguyen, H. & Hoffmann, A. A. (2016). Mitochondrial DNA variants help monitor the dynamics of Wolbachia invasion into host populations. HEREDITY, 116 (3), pp.265-276. https://doi.org/10.1038/hdy.2015.97.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/258403
    DOI
    10.1038/hdy.2015.97
    Abstract
    Wolbachia is the most widespread endosymbiotic bacterium of insects and other arthropods that can rapidly invade host populations. Deliberate releases of Wolbachia into natural populations of the dengue fever mosquito, Aedes aegypti, are used as a novel biocontrol strategy for dengue suppression. Invasion of Wolbachia through the host population relies on factors such as high fidelity of the endosymbiont transmission and limited immigration of uninfected individuals, but these factors can be difficult to measure. One way of acquiring relevant information is to consider mitochondrial DNA (mtDNA) variation alongside Wolbachia in field-caught mosquitoes. Here we used diagnostic mtDNA markers to differentiate infection-associated mtDNA haplotypes from those of the uninfected mosquitoes at release sites. Unique haplotypes associated with Wolbachia were found at locations outside Australia. We also performed mathematical and qualitative analyses including modelling the expected dynamics of the Wolbachia and mtDNA variants during and after a release. Our analyses identified key features in haplotype frequency patterns to infer the presence of imperfect maternal transmission of Wolbachia, presence of immigration and possibly incomplete cytoplasmic incompatibility. We demonstrate that ongoing screening of the mtDNA variants should provide information on maternal leakage and immigration, particularly in releases outside Australia. As we demonstrate in a case study, our models to track the Wolbachia dynamics can be successfully applied to temporal studies in natural populations or Wolbachia release programs, as long as there is co-occurring mtDNA variation that differentiates infected and uninfected populations.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [45689]
    • School of BioSciences - Research Publications [1092]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors