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dc.contributor.authorHARRIS, AW
dc.contributor.authorPINKERT, CA
dc.contributor.authorCRAWFORD, M
dc.contributor.authorLANGDON, WY
dc.contributor.authorBRINSTER, RL
dc.contributor.authorADAMS, JM
dc.date.accessioned2020-12-22T06:11:34Z
dc.date.available2020-12-22T06:11:34Z
dc.date.issued1988-02-01
dc.identifier.citationHARRIS, A. W., PINKERT, C. A., CRAWFORD, M., LANGDON, W. Y., BRINSTER, R. L. & ADAMS, J. M. (1988). THE E-MU-MYC TRANSGENIC MOUSE - A MODEL FOR HIGH-INCIDENCE SPONTANEOUS LYMPHOMA AND LEUKEMIA OF EARLY B-CELLS. JOURNAL OF EXPERIMENTAL MEDICINE, 167 (2), pp.353-371. https://doi.org/10.1084/jem.167.2.353.
dc.identifier.issn0022-1007
dc.identifier.urihttp://hdl.handle.net/11343/258429
dc.description.abstractMice transgenic for a c-myc gene driven by the IgH enhancer (E mu-myc) were shown to almost invariably develop lymphomas, 90% succumbing in the first 5 mo of life. The tumors typically presented as rapidly progressive lymphadenopathy with thymic involvement and were highly malignant by transplantation assay. Morphologically, they were lymphoblastic lymphomas, usually accompanied by lymphoid leukemia and granulocytosis, and were distinct from the tumors that arose much later in 37% of nontransgenic mice of the same (C57BL/6 x SJL)F2 genetic background. Cell-surface markers on 31 E mu-myc tumors identified 52% as pre-B lymphomas, 29% as mixed pre-B and B lymphomas, and 19% as B lymphomas. The tumors appeared to arise at random from a population of pre-B cells expanded by constitutive expression of the myc transgene. A majority of the animals initiated malignancy at the rate of 17% per week. The rate at which the cycling, benign pre-B cells spontaneously convert to malignancy was estimated to about 10(-10) per cell per generation. A transient leukocytosis identified in young E mu-myc mice was developed into a rapid assay for inheritance of the transgene.
dc.languageEnglish
dc.publisherROCKEFELLER UNIV PRESS
dc.titleTHE E-MU-MYC TRANSGENIC MOUSE - A MODEL FOR HIGH-INCIDENCE SPONTANEOUS LYMPHOMA AND LEUKEMIA OF EARLY B-CELLS
dc.typeJournal Article
dc.identifier.doi10.1084/jem.167.2.353
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.source.titleJournal of Experimental Medicine
melbourne.source.volume167
melbourne.source.issue2
melbourne.source.pages353-371
dc.rights.licenseCC BY-NC-SA
melbourne.elementsid1195297
melbourne.contributor.authorAdams, Jerry
dc.identifier.eissn1540-9538
melbourne.accessrightsOpen Access


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