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dc.contributor.authorRasmussen, TA
dc.contributor.authorJensen, D
dc.contributor.authorTolstrup, M
dc.contributor.authorNielsen, US
dc.contributor.authorErlandsen, EJ
dc.contributor.authorBirn, H
dc.contributor.authorOstergaard, L
dc.contributor.authorLangdahl, BL
dc.contributor.authorLaursen, AL
dc.date.accessioned2020-12-22T06:14:12Z
dc.date.available2020-12-22T06:14:12Z
dc.date.issued2012-03-29
dc.identifierpii: PONE-D-11-24497
dc.identifier.citationRasmussen, T. A., Jensen, D., Tolstrup, M., Nielsen, U. S., Erlandsen, E. J., Birn, H., Ostergaard, L., Langdahl, B. L. & Laursen, A. L. (2012). Comparison of Bone and Renal Effects In HIV-infected Adults Switching to Abacavir or Tenofovir Based Therapy in a Randomized Trial. PLOS ONE, 7 (3), https://doi.org/10.1371/journal.pone.0032445.
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11343/258438
dc.description.abstractINTRODUCTION: Our objective was to compare the bone and renal effects among HIV-infected patients randomized to abacavir or tenofovir-based combination anti-retroviral therapy. METHODS: In an open-label randomized trial, HIV-infected patients were randomized to switch from zidovudine/lamivudine (AZT/3TC) to abacavir/lamivudine (ABC/3TC) or tenofovir/emtricitabine (TDF/FTC). We measured bone mass density (BMD) and bone turnover biomarkers (osteocalcin, osteocalcin, procollagen type 1 N-terminal propeptide (P1NP), alkaline phosphatase, type I collagen cross-linked C-telopeptide (CTx), and osteoprotegerin). We assessed renal function by estimated creatinine clearance, plasma cystatin C, and urinary levels of creatinine, albumin, cystatin C, and neutrophil gelatinase-associated lipocalin (NGAL). The changes from baseline in BMD and renal and bone biomarkers were compared across study arms. RESULTS: Of 40 included patients, 35 completed 48 weeks of randomized therapy and follow up. BMD was measured in 33, 26, and 27 patients at baseline, week 24, and week 48, respectively. In TDF/FTC-treated patients we observed significant reductions from baseline in hip and lumbar spine BMD at week 24 (-1.8% and -2.5%) and week 48 (-2.1% and -2.1%), whereas BMD was stable in patients in the ABC/3TC arm. The changes from baseline in BMD were significantly different between study arms. All bone turnover biomarkers except osteoprotegerin increased in the TDF/FTC arm compared with the ABC/3TC arm, but early changes did not predict subsequent loss of BMD. Renal function parameters were similar between study arms although a small increase in NGAL was detected among TDF-treated patients. CONCLUSION: Switching to TDF/FTC-based therapy led to decreases in BMD and increases in bone turnover markers compared with ABC/3TC-based treatment. No major difference in renal function was observed. TRIAL REGISTRATION: Clinicaltrials.gov NCT00647244.
dc.languageEnglish
dc.publisherPUBLIC LIBRARY SCIENCE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleComparison of Bone and Renal Effects In HIV-infected Adults Switching to Abacavir or Tenofovir Based Therapy in a Randomized Trial
dc.typeJournal Article
dc.identifier.doi10.1371/journal.pone.0032445
melbourne.affiliation.departmentDoherty Institute
melbourne.source.titlePLoS One
melbourne.source.volume7
melbourne.source.issue3
dc.rights.licenseCC BY
melbourne.elementsid1195938
melbourne.contributor.authorRasmussen, Thomas
dc.identifier.eissn1932-6203
melbourne.accessrightsOpen Access


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