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    The investigation of bone fracture healing under intramembranous and endochondral ossification.

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    Author
    Ghimire, S; Miramini, S; Edwards, G; Rotne, R; Xu, J; Ebeling, P; Zhang, L
    Date
    2021-06
    Source Title
    Bone Reports
    Publisher
    Elsevier BV
    University of Melbourne Author/s
    Zhang, Lihai; Miramini, Seyedsaeed
    Affiliation
    Infrastructure Engineering
    Metadata
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    Document Type
    Journal Article
    Citations
    Ghimire, S., Miramini, S., Edwards, G., Rotne, R., Xu, J., Ebeling, P. & Zhang, L. (2021). The investigation of bone fracture healing under intramembranous and endochondral ossification.. Bone Rep, 14, pp.100740-. https://doi.org/10.1016/j.bonr.2020.100740.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/258829
    DOI
    10.1016/j.bonr.2020.100740
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772545
    Abstract
    After trauma, fractured bone starts healing directly through bone union or indirectly through callus formation process. Intramembranous and endochondral ossification are two commonly known mechanisms of indirect healing. The present study investigated the bone fracture healing under intramembranous and endochondral ossification by developing theoretical models in conjunction with performing a series of animal experiments. Using experimentally determined mean bone densities in sheep tibia stabilized by the Locking Compression Plate (LCP) fixation system, the research outcomes showed that intramembranous and endochondral ossification can be described by Hill Function with two unique sets of function parameters in mechanical stimuli mediated fracture healing. Two different thresholds exist within the range of mechanical simulation index which could trigger significant intramembranous and endochondral ossification, with a relatively higher bone formation rate of endochondral ossification than that of intramembranous ossification. Furthermore, the increase of flexibility of the LCP system and the use of titanium LCP could potentially promote uniform bone formation across the fracture gap, ultimately better healing outcomes.

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