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    QSMART: Quantitative Susceptibility Mapping Artifact Reduction Technique

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    Author
    Yaghmaie, N; Syeda, W; Wu, C; Zhang, Y; Zhang, TD; Burrows, EL; Brodtmann, A; Moffat, BA; Wright, DK; Glarin, R; ...
    Date
    2021-01-20
    Source Title
    NeuroImage
    Publisher
    Elsevier
    University of Melbourne Author/s
    Johnston, Leigh; Kolbe, Scott
    Affiliation
    Biomedical Engineering
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Yaghmaie, N., Syeda, W., Wu, C., Zhang, Y., Zhang, T. D., Burrows, E. L., Brodtmann, A., Moffat, B. A., Wright, D. K., Glarin, R., Kolbe, S. & Johnston, L. (2021). QSMART: Quantitative Susceptibility Mapping Artifact Reduction Technique. NeuroImage, 231, https://doi.org/10.1016/j.neuroimage.2020.117701.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/258852
    DOI
    10.1016/j.neuroimage.2020.117701
    Open Access URL
    https://www.sciencedirect.com/science/article/pii/S1053811920311861?via%3Dihub
    Abstract
    PURPOSE: Quantitative susceptibility mapping (QSM) is a novel MR technique that allows mapping of tissue susceptibility values from MR phase images. QSM is an ill-conditioned inverse problem, and although several methods have been proposed in the field, in the presence of a wide range of susceptibility sources, streaking artifacts appear around high susceptibility regions and contaminate the whole QSM map. QSMART is a post-processing pipeline that uses two-stage parallel inversion to reduce the streaking artifacts and remove banding artifact at the cortical surface and around the vasculature. METHOD: Tissue and vein susceptibility values were separately estimated by generating a mask of vasculature driven from the magnitude data using a Frangi filter. Spatially dependent filtering was used for the background field removal step and the two susceptibility estimates were combined in the final QSM map. QSMART was compared to RESHARP/iLSQR and V-SHARP/iLSQR inversion in a numerical phantom, 7T in vivo single and multiple-orientation scans, 9.4T ex vivo mouse data, and 4.7T in vivo rat brain with induced focal ischemia. RESULTS: Spatially dependent filtering showed better suppression of phase artifacts near cortex compared to RESHARP and V-SHARP, while preserving voxels located within regions of interest without brain edge erosion. QSMART showed successful reduction of streaking artifacts as well as improved contrast between different brain tissues compared to the QSM maps obtained by RESHARP/iLSQR and V-SHARP/iLSQR. CONCLUSION: QSMART can reduce QSM artifacts to enable more robust estimation of susceptibility values in vivo and ex vivo.

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