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dc.contributor.authorYaghmaie, N
dc.contributor.authorSyeda, W
dc.contributor.authorWu, C
dc.contributor.authorZhang, Y
dc.contributor.authorZhang, TD
dc.contributor.authorBurrows, EL
dc.contributor.authorBrodtmann, A
dc.contributor.authorMoffat, BA
dc.contributor.authorWright, DK
dc.contributor.authorGlarin, R
dc.contributor.authorKolbe, S
dc.contributor.authorJohnston, L
dc.date.accessioned2021-01-27T13:01:42Z
dc.date.available2021-01-27T13:01:42Z
dc.date.issued2021-01-20
dc.identifierpii: S1053-8119(20)31186-1
dc.identifier.citationYaghmaie, N., Syeda, W., Wu, C., Zhang, Y., Zhang, T. D., Burrows, E. L., Brodtmann, A., Moffat, B. A., Wright, D. K., Glarin, R., Kolbe, S. & Johnston, L. (2021). QSMART: Quantitative Susceptibility Mapping Artifact Reduction Technique. NeuroImage, 231, https://doi.org/10.1016/j.neuroimage.2020.117701.
dc.identifier.issn1053-8119
dc.identifier.urihttp://hdl.handle.net/11343/258852
dc.description.abstractPURPOSE: Quantitative susceptibility mapping (QSM) is a novel MR technique that allows mapping of tissue susceptibility values from MR phase images. QSM is an ill-conditioned inverse problem, and although several methods have been proposed in the field, in the presence of a wide range of susceptibility sources, streaking artifacts appear around high susceptibility regions and contaminate the whole QSM map. QSMART is a post-processing pipeline that uses two-stage parallel inversion to reduce the streaking artifacts and remove banding artifact at the cortical surface and around the vasculature. METHOD: Tissue and vein susceptibility values were separately estimated by generating a mask of vasculature driven from the magnitude data using a Frangi filter. Spatially dependent filtering was used for the background field removal step and the two susceptibility estimates were combined in the final QSM map. QSMART was compared to RESHARP/iLSQR and V-SHARP/iLSQR inversion in a numerical phantom, 7T in vivo single and multiple-orientation scans, 9.4T ex vivo mouse data, and 4.7T in vivo rat brain with induced focal ischemia. RESULTS: Spatially dependent filtering showed better suppression of phase artifacts near cortex compared to RESHARP and V-SHARP, while preserving voxels located within regions of interest without brain edge erosion. QSMART showed successful reduction of streaking artifacts as well as improved contrast between different brain tissues compared to the QSM maps obtained by RESHARP/iLSQR and V-SHARP/iLSQR. CONCLUSION: QSMART can reduce QSM artifacts to enable more robust estimation of susceptibility values in vivo and ex vivo.
dc.languageeng
dc.publisherElsevier
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titleQSMART: Quantitative Susceptibility Mapping Artifact Reduction Technique
dc.typeJournal Article
dc.identifier.doi10.1016/j.neuroimage.2020.117701
melbourne.affiliation.departmentBiomedical Engineering
melbourne.source.titleNeuroImage
melbourne.source.volume231
melbourne.source.pages117701-
dc.rights.licenseCC BY-NC-ND
melbourne.elementsid1491436
melbourne.openaccess.urlhttps://www.sciencedirect.com/science/article/pii/S1053811920311861?via%3Dihub
melbourne.openaccess.statusAccepted version
melbourne.contributor.authorJohnston, Leigh
melbourne.contributor.authorKolbe, Scott
dc.identifier.eissn1095-9572
melbourne.accessrightsOpen Access


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